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Nature 424, 738-739 (14 August 2003) | doi:10.1038/424738a

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Signal transduction: Aspirin, ubiquitin and cancer

Keith D. Wilkinson1

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Tumours sidestep the body's rules and regulations in myriad ways. The latest discovery ties together a benign tumour syndrome with two hot subjects of biological research: the proteins NF-kappaB and ubiquitin.

There are few fields of biology as complicated as the study of cancer. The alphabet soup of abbreviations and acronyms challenges our understanding of an already bewildering array of aberrant cellular signalling pathways.

  1. Department of Biochemistry, 4017 Rollins Research Building, 1510 Clifton Road, Emory University, Atlanta, Georgia 30322, USA.
    Email: genekdw@emory.edu