Tumours sidestep the body's rules and regulations in myriad ways. The latest discovery ties together a benign tumour syndrome with two hot subjects of biological research: the proteins NF-κB and ubiquitin.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Brummelkamp, T. R., Nijman, S. M. B., Dirac, A. M. G. & Bernards, R. Nature 424, 797–801 (2003).
Kovalenko, A. et al. Nature 424, 801–805 (2003).
Trompouki, E. et al. Nature 424, 793–796 (2003).
Biggs, P. J. et al. Nature Genet. 11, 441–443 (1995).
Bignell, G. R. et al. Nature Genet. 25, 160–165 (2000).
Chen, G. & Goeddel, D. V. Science 296, 1634–1635 (2002).
Ben-Neriah, Y. Nature Immunol. 3, 20–26 (2002).
Amit, S. & Ben-Neriah, Y. Semin. Cancer Biol. 13, 15–28 (2003).
Wang, C. et al. Nature 412, 346–351 (2001).
Deng, L. et al. Cell 103, 351–361 (2000).
Borodovsky, A. et al. Chem. Biol. 9, 1149–1159 (2002).
Li, X., Yang, Y. & Ashwell, J. D. Nature 416, 345–347 (2002).
Evans, P. C. et al. J. Biol. Chem. 278, 23180–23186 (2003).
Zhang, S. Q., Kovalenko, A., Cantarella, G. & Wallach, D. Immunity 12, 301–311 (2000).
Richardson, P. Cancer Treat. Rev. 29 (Suppl. 1), 33–39 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Wilkinson, K. Aspirin, ubiquitin and cancer. Nature 424, 738–739 (2003). https://doi.org/10.1038/424738a
Issue Date:
DOI: https://doi.org/10.1038/424738a
This article is cited by
-
Ubiquitin and ubiquitin-like proteins as multifunctional signals
Nature Reviews Molecular Cell Biology (2005)
-
De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-κB signalling
Nature (2004)
-
Cylindromatosis: cause and treatment
Nature Reviews Cancer (2003)
-
To be, or not to be: NF-κB is the answer – role of Rel/NF-κB in the regulation of apoptosis
Oncogene (2003)