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Nature 423, 593-595 (5 June 2003) |
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PhD - Helmholtz International Graduate School for Infection Research
- Helmholtz-Zentrum fur Infektionsforschung
- Braunschweig Germany
Junior Research Groups (W1 / W2)
- Cluster of Excellence "Multimodal Computing and Interaction"
- Saarbruecken Germany
Cancer: Out of air is not out of action
Donald P. Bottaro & Lance A. Liotta
Abstract
Starving cancers of oxygen would seem to be a good way of killing them, but the presence of oxygen-deprived areas in tumours appears to correlate with poor prognosis. A molecular explanation for this has now been found.
When cells are starved of oxygen, they usually die. This is why numerous anti-cancer treatments aim to prevent the growth of blood vessels in tumours, thereby cutting off their oxygen supply.
- Donald P. Bottaro is in the Urologic Oncology Branch, and Lance A. Liotta is in the Invasion and Metastasis Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892-1500, USA.
Correspondence to: Lance A. Liotta e-mail: Email: liottal@mail.nih.gov
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