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Nature 423, 390-391 (22 May 2003) | doi:10.1038/423390a
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Gene expression: Silent clones speak up
Wolf Reik & Wendy Dean
Abstract
An important category of genes — so-called pluripotency genes — are active in early embryos but silent in specialized cells. It seems that this silencing is difficult to reverse in cloned embryos.
Early on in the development of an embryo, the cells that are produced can contribute to a wide range of tissue types. But as development proceeds they become less and less 'pluripotent', as they are tailored towards specific functions.
- Wolf Reik and Wendy Dean are in the Laboratory of Developmental Genetics and Imprinting, The Babraham Institute, Cambridge CB2 4AT, UK.
Correspondence to: e-mail: Email: wolf.reik@bbsrc.ac.uk
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