Table of contents
Volume 423 Number 6937 pp207-365
Editorials
Don't mention the war... p207
The United States could taint the ITER project to build a prototype magnetic-confinement fusion reactor if it exploits the selection of a site to settle diplomatic scores. But its European partners don't need to let that happen.
doi:10.1038/423207a
Gene patents and the public good p207
A race to claim patents on the SARS virus raises questions about the patent system's ability to cope with genomics.
doi:10.1038/423207b
News
Biologists take tentative steps towards bespoke cancer drugs p209
David Cyranoski
Researchers rue hasty destruction of wheat p210
Carina Dennis
Cash crisis casts pall over synchrotron X-ray source p210
Carina Dennis
doi:10.1038/423210b
US support for Spain triggers unease over fusion project p211
Geoff Brumfiel and Declan Butler
doi:10.1038/423211a
Medical council pins hopes on public advocate of science p211
Jim Giles
doi:10.1038/423211b
Europe dithers as Canada cuts cod fishing p212
Quirin Schiermeier
doi:10.1038/423212a
Asteroid probe to test technologies p212
David Cyranoski
doi:10.1038/423212b
Low embryo count fuels US stem-cell debate p213
Kendall Powell
doi:10.1038/423213a
MIT pulls out of Asian Media Lab in argument over role p213
K. S. Jayaraman
doi:10.1038/423213b
News feature
The man they love to hate p216
Bjørn Lomborg is reviled by green activists and has come under ferocious attack from many environmental scientists. Just why does he provoke such strong reactions, and how influential might his opinions become? Jim Giles investigates.
Jim Giles
doi:10.1038/423216a
Conservation biology: Mock turtles p219
One reptile enthusiast, working with a handful of academics, has described a clutch of new Asian turtle species since the late 1980s. But are they what they seem? Rex Dalton reports on a herpetological débâcle.
Rex Dalton
doi:10.1038/423219a
Correspondence
Japanese system buries the individual researcher p221
The hierarchy ensures that young scientists' grants are absorbed into the lab's budget.
Ippeita Dan
doi:10.1038/423221a
Early work on elephant gait not to be forgotten p221
Oliver Sacks
doi:10.1038/423221b
Making a song and dance about emotion p221
Rupert C. Marshall
doi:10.1038/423221c
Book Reviews
The X and Y of sex p223
The sex chromosomes, especially the degenerate Y, have a lot to answer for.
Jennifer A. Marshall Graves reviews The X in Sex: How the Chromosome Controls our Lives by David Bainbridge and Y: The Descent of Men by Steve Jones
doi:10.1038/423223a
The Harvard blood group p224
Charles Tanford and Jacqueline Reynolds review Edwin J. Cohn and the Development of Protein Chemistry: With a Detailed Account of His Work on the Fractionation of Blood During and After World War II by Douglas M. Surgenor
doi:10.1038/423224a
Heading for safer shores? p225
N. Mrosovsky reviews The Biology of Sea Turtles, Volume II
doi:10.1038/423225a
Balancing planets and molecules p225
David W. Schindler reviews Ecological Stoichiometry: The Biology of Elements from Molecules to the Biosphere by Robert W. Sterner and James J. Elser
doi:10.1038/423225b
Science in culture p226
Alison Abbott reviews
doi:10.1038/423226a
News and Views
Plant reproduction: Sex and self-denial p229
Many plants are self-incompatible — that is, they have mechanisms to prevent fertilization by their own pollen. A familiar and uncommonly versatile protein, ubiquitin, is found to be a central player in one such system.
Ed Newbigin and Richard D. Vierstra
doi:10.1038/423229a
Cosmology: A just-so story p230
Physicists are learning to live with Einstein's 'fudge factor', the cosmological constant. New thinking attempts to tie its value to other fundamental constants in elementary particle physics.
Lawrence M. Krauss
doi:10.1038/423230a
Stem cells: Self-renewal writ in blood p231
The ability to self-renew is a defining property of stem cells, and a protein in blood stem cells that controls their self-renewal has been discovered. That same protein is also crucial for the development of leukaemia.
John E. Dick
doi:10.1038/423231a
100 and 50 years ago p232
doi:10.1038/423232a
Genomics: Yeast rises again p233
What's in a genome? The short answer is that you can't really say in detail for any one species until you have the genome sequences of a variety of other species — some closely related, others less so — to compare it with.
Steven L. Salzberg
doi:10.1038/423233a
Molecular biology: Disruptive influence p234
Recombination is a vital cellular process implicated in DNA metabolism — but it must be tightly controlled. The discovery of a protein that disrupts recombination intermediates sheds light on the control mechanisms.
Marco Foiani
doi:10.1038/423234a
Planetary science: Jupiter's moonopoly p235
A further 23 satellites have been discovered in orbit around Jupiter. With diameters of between two and eight kilometres, the moons are the smallest yet spotted around any planet.
Douglas P. Hamilton
doi:10.1038/423235a
Corrections p236
doi:10.1038/423236a
Obituary: Charles A. Janeway Jr (1943–2003) p237
William E. Paul and Ronald N. Germain
doi:10.1038/423237a
news and views in brief p238
doi:10.1038/423238a
Brief Communications
Planetary science: Mission to Earth's core — a modest proposal p239
Not science fiction, but a technically feasible plan to probe our planet's inner workings.
David J. Stevenson
doi:10.1038/423239a
First paragraph | Full Text | PDF (181K)
Aetiology: Koch's postulates fulfilled for SARS virus p240
Ron A. M. Fouchier, Thijs Kuiken, Martin Schutten, Geert van Amerongen, Gerard J. J. van Doornum, Bernadette G. van den Hoogen, Malik Peiris, Wilina Lim, Klaus Stöhr and Albert D. M. E. Osterhaus
doi:10.1038/423240a
First paragraph | Full Text | PDF (156K) | Supplementary information
Articles
Sequencing and comparison of yeast species to identify genes and regulatory elements p241
Manolis Kellis, Nick Patterson, Matthew Endrizzi, Bruce Birren and Eric S. Lander
doi:10.1038/nature01644
Abstract | Full Text | PDF (2,232K) | Supplementary information
See also: News and Views by Salzberg
Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells p255
Julie Lessard and Guy Sauvageau
doi:10.1038/nature01572
Abstract | Full Text | PDF (610K) | Supplementary information
See also: News and Views by Dick
Letters to Nature
An abundant population of small irregular satellites around Jupiter p261
Scott S. Sheppard and David C. Jewitt
doi:10.1038/nature01584
First paragraph | Full Text | PDF (186K)
See also: News and Views by Hamilton
Chaos-assisted capture of irregular moons p264
Sergey A. Astakhov, Andrew D. Burbanks, Stephen Wiggins and David Farrelly
doi:10.1038/nature01622
First paragraph | Full Text | PDF (432K)
A theory of power-law distributions in financial market fluctuations p267
Xavier Gabaix, Parameswaran Gopikrishnan, Vasiliki Plerou and H. Eugene Stanley
doi:10.1038/nature01624
First paragraph | Full Text | PDF (198K) | Supplementary information
Measurement of the displacement field of dislocations to 0.03 Å by electron microscopy p270
Martin J. Hÿtch, Jean-Luc Putaux and Jean-Michel Pénisson
doi:10.1038/nature01638
First paragraph | Full Text | PDF (671K)
Detection of bromine monoxide in a volcanic plume p273
N. Bobrowski, G. Hönninger, B. Galle and U. Platt
doi:10.1038/nature01625
First paragraph | Full Text | PDF (442K)
Parallel extinction risk and global distribution of languages and species p276
William J. Sutherland
doi:10.1038/nature01607
First paragraph | Full Text | PDF (336K)
Rapid worldwide depletion of predatory fish communities p280
Ransom A. Myers and Boris Worm
doi:10.1038/nature01610
First paragraph | Full Text | PDF (635K) | Supplementary information
Attractor dynamics of network UP states in the neocortex p283
Rosa Cossart, Dmitriy Aronov and Rafael Yuste
doi:10.1038/nature01614
First paragraph | Full Text | PDF (583K) | Supplementary information
Turning on and off recurrent balanced cortical activity p288
Yousheng Shu, Andrea Hasenstaub and David A. McCormick
doi:10.1038/nature01616
First paragraph | Full Text | PDF (998K) | Supplementary information
Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome p293
Maria Eriksson, W. Ted Brown, Leslie B. Gordon, Michael W. Glynn, Joel Singer, Laura Scott, Michael R. Erdos, Christiane M. Robbins, Tracy Y. Moses, Peter Berglund, Amalia Dutra, Evgenia Pak, Sandra Durkin, Antonei B. Csoka, Michael Boehnke, Thomas W. Glover and Francis S. Collins
doi:10.1038/nature01629
First paragraph | Full Text | PDF (538K) | Supplementary information
A progeroid syndrome in mice is caused by defects in A-type lamins p298
Leslie C. Mounkes, Serguei Kozlov, Lidia Hernandez, Teresa Sullivan and Colin L. Stewart
doi:10.1038/nature01631
First paragraph | Full Text | PDF (452K) | Supplementary information
Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells p302
In-kyung Park, Dalong Qian, Mark Kiel, Michael W. Becker, Michael Pihalja, Irving L. Weissman, Sean J. Morrison and Michael F. Clarke
doi:10.1038/nature01587
First paragraph | Full Text | PDF (336K) | Supplementary information
See also: News and Views by Dick
DNA helicase Srs2 disrupts the Rad51 presynaptic filament p305
Lumir Krejci, Stephen Van Komen, Ying Li, Jana Villemain, Mothe Sreedhar Reddy, Hannah Klein, Thomas Ellenberger and Patrick Sung
doi:10.1038/nature01577
First paragraph | Full Text | PDF (418K)
See also: News and Views by Foiani
The Srs2 helicase prevents recombination by disrupting Rad51 nucleoprotein filaments p309
Xavier Veaute, Josette Jeusset, Christine Soustelle, Stephen C. Kowalczykowski, Eric Le Cam and Francis Fabre
doi:10.1038/nature01585
First paragraph | Full Text | PDF (265K)
See also: News and Views by Foiani
New on the Market
Chromatography developments p313
Acronyms abound in two pages devoted to GC, TLC, GPC, HPLC etc.
doi:10.1038/423313a
Insight
introductionbone and cartilage p315
Natalie DeWitt
doi:10.1038/423315a
Overview
The complexities of skeletal biology p316
Gerard Karsenty
doi:10.1038/nature01654
Abstract | Full Text | PDF (163K)
Review article
Deciphering skeletal patterning: clues from the limb p319
Francesca V. Mariani and Gail R. Martin
doi:10.1038/nature01655
Abstract | Full Text | PDF (578K)
Cranial skeletal biology p326
J. A. Helms and R. A. Schneider
doi:10.1038/nature01656
Abstract | Full Text | PDF (840K)
Developmental regulation of the growth plate p332
Henry M. Kronenberg
doi:10.1038/nature01657
Abstract | Full Text | PDF (269K)
Osteoclast differentiation and activation p337
William J. Boyle, W. Scott Simonet and David L. Lacey
doi:10.1038/nature01658
Abstract | Full Text | PDF (520K)
The genetic basis for skeletal diseases p343
Elazar Zelzer and Bjorn R. Olsen
doi:10.1038/nature01659
Abstract | Full Text | PDF (271K)
Control of osteoblast function and regulation of bone mass p349
Shun-ichi Harada and Gideon A. Rodan
doi:10.1038/nature01660
Abstract | Full Text | PDF (448K)
Evolving concepts of rheumatoid arthritis p356
Gary S. Firestein
doi:10.1038/nature01661
Abstract | Full Text | PDF (414K)
Naturejobs
ProspectsBiotech's balancing act p363
Paul Smaglik
doi:10.1038/nj6937-363a
Regions
Heidelberg: Language lessons p364
Paul Smaglik
doi:10.1038/nj6937-364a
