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Nature 422, 827-828 (24 April 2003) | doi:10.1038/422827a
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Cancer: Escape from inhibition
Sara A. Courtneidge
Abstract
Mutations in the Abl protein cause some leukaemias. The determination of its structure and the identification of Abl variants resistant to an anti-leukaemia drug reveal regions of the protein needed for its regulation.
The enigmatic protein Abl has just given up another of its secrets. This enzyme is important because in mutated, activated form it causes some types of human leukaemia — so researchers have been keen to learn how it is regulated.
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