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Nature 422, 198-207 (13 March 2003) | doi:10.1038/nature01511
Open Innovation Challenges
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Protect Enzyme from In Planta Degradation
A proposal for stable expression of an enzyme in corn seed is desired.
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Fast Growth of Transformed Soybean Shoots
A method for accelerating growth of soybean shoots is desired.
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Postdoctoral Position, Endocrine Unit
- MGH-Harvard Medical School
- MGH, 50 Blossom Street, Boston MA 02114
Senior Research Associate ? Immunology
- Genentech
- South San Francisco, CA, USA
review article Mass spectrometry-based proteomics
Ruedi Aebersold1 & Matthias Mann2
Abstract
Recent successes illustrate the role of mass spectrometry-based proteomics as an indispensable tool for molecular and cellular biology and for the emerging field of systems biology. These include the study of protein–protein interactions via affinity-based isolations on a small and proteome-wide scale, the mapping of numerous organelles, the concurrent description of the malaria parasite genome and proteome, and the generation of quantitative protein profiles from diverse species. The ability of mass spectrometry to identify and, increasingly, to precisely quantify thousands of proteins from complex samples can be expected to impact broadly on biology and medicine.
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