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Nature 421, 903-904 (27 February 2003) | doi:10.1038/421903a
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Developmental biology: A twist in a mouse tale
Nick Dyson
Abstract
Studies of the retinoblastoma gene can still deliver surprises, and enlightenment. Several of the abnormalities in mice lacking this gene are, it seems, the indirect consequence of a placental defect.
On page 942 of this issue, Wu et al.1 describe a surprising new observation about the function of Rb, the gene that is mutated in retinoblastoma cancers. Rb is often described as a prototype for tumour suppressors — that priceless category of genes that, among other tasks, protect us from developing cancers — as it was the first gene of this type to be identified.
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