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double helix
Nature 421, 444-448 (23 January 2003) | doi:10.1038/nature01410
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Chief Scientific Manager - Medicinal Chemistry
- Syngene International
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- Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215
feature The digital code of DNA
Abstract
The discovery of the structure of DNA transformed biology profoundly, catalysing the sequencing of the human genome and engendering a new view of biology as an information science. Two features of DNA structure account for much of its remarkable impact on science: its digital nature and its complementarity, whereby one strand of the helix binds perfectly with its partner. DNA has two types of digital information — the genes that encode proteins, which are the molecular machines of life, and the gene regulatory networks that specify the behaviour of the genes.
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