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Nature 421, 125-126 (9 January 2003) | doi:10.1038/421125a
Open Innovation Challenges
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Fast Growth of Transformed Soybean Shoots
A method for accelerating growth of soybean shoots is desired.
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Protect Enzyme from In Planta Degradation
A proposal for stable expression of an enzyme in corn seed is desired.
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2 Post-Doctoral Positions
- German Cancer Research Center
- Heidelberg 69120 Germany
Assistant Professor in Pharmacology
- St. George University
- Grenada, West Indies
Physiology: Cost-free longevity in mice?
Gordon J. Lithgow & Matthew S. Gill
Abstract
Studies of worms have revealed hundreds of proteins that, when mutated, extend lifespan. Can this work tell us anything about mammalian ageing? A look at the effects of one such protein on lab mice suggests that it can.
Just over five years ago, molecular geneticists working with the microscopic worm Caenorhabditis elegans made an intriguing discovery1 about a protein that, when its activity is reduced, doubles the animal's lifespan2. They found that the protein — DAF-2 — is structurally similar to the human receptor proteins that allow cells to respond to insulin or insulin-like growth factors (IGF).
- Gordon J. Lithgow and Matthew S. Gill are at The Buck Institute, 8001 Redwood Boulevard, Novato, California 94949, USA.
Correspondence to: Gordon J. Lithgow e-mail: Email: glithgow@buckinstitute.org
Correspondence to: Matthew S. Gill e-mail: Email: mgill@buckinstitute.org
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