Supplementary information
From the following article:
Numerous potentially functional but non-genic conserved sequences on human chromosome 21
Emmanouil T. Dermitzakis, Alexandre Reymond, Robert Lyle, Nathalie Scamuffa, Catherine Ucla, Samuel Deutsch, Brian J. Stevenson, Volker Flegel, Philipp Bucher, C. Victor Jongeneel and Stylianos E. Antonarakis
Nature 420, 578-582(5 December 2002)
doi:10.1038/nature01251
The distributions of distances between consecutive substitutions in subsets of unknown blocks positive for Grail, Affymetrix, QRNA and GenomeScan.
Tables of p-distance and Jules-Cantor distance between human, mouse and rabbit.
FASTA format of all human 1229 known conserved blocks.
FASTA format of all human 2262 unknown conserved blocks.
Coordinates, position in sequence, length and other information for all 2262 unknown blocks and genes around them. (note that each block has a numerical code which in the FASTA files is shown as hs(2 MB)
Worksheet indicating the number of substitutions that are inferred to occur in each of the human, mouse and rabbit lineages.
Table 1: showing the number of known and unknown conserved blocks that satisfied each of the criteria for functional transcription potential.
Evidence for functional transcription (Figure 3) for each of the 2262 unknown blocks as inferred from the 6 criteria mentioned in the paper.
List of the human and mouse sequences in FASTA format used in the 3-way comparison analysis. The corresponding rabbit sequences can be found in the /Rabbit/ Folder.
Description of the methods for the analysis of the 111 human, mouse and rabbit alignments.
Folder that contains all the 111 rabbit sequences in separate FASTA files (text documents) that were aligned to the human and mouse sequences to perform the 3-way analysis. The numbers in the names ra(144 KB)
Genbank accession numbers of the mouse genome sequence syntenic to human chromosome 21.
Genbank accession numbers for the 111 rabbit sequences.
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