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Nature 420, 135-138 (14 November 2002) | doi:10.1038/420135a
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Three Associate Senior Lecturer positions within Natural Sciences
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Medicine: Lipid signals in pain control
Nicolas G. Bazan1 & Rod J. Flower2
Abstract
Cyclooxygenase enzymes produce lipid messenger molecules whose roles in health or disease depend on their context. The discovery of cyclooxygenase-3 should enhance our knowledge of such events.
Some of the most widely used medicines today are aspirin and other such nonsteroidal anti-inflammatory drugs (NSAIDs), which are well known for their pain-relieving, fever-reducing and anti-inflammatory effects. Simply put, these drugs work mainly by inhibiting the formation of prostaglandins — potent lipid messenger molecules — and they do this by blocking cellular cyclooxygenase enzymes, of which two have previously been discovered.
- Nicolas G. Bazan is at the LSU Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center, 2020 Gravier Street, Suite D, New Orleans, Louisiana 70112, USA.
e-mail: Email: nbazan@lsuhsc.edu - Rod J. Flower is at the William Harvey Research Institute, Charterhouse Square, London EC1M 6BQ, UK.
e-mail: Email: r.j.flower@qmul.ac.uk
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