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Nature 419, 795-797 (24 October 2002) | doi:10.1038/419795a
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Cancer: Pinning a change on p53
Kevin M. Ryan & Karen H. Vousden
Abstract
An enzyme-induced conformational change is now implicated in activating the p53 protein, one of a cell's prime movers in preventing tumour development.
One in three of us will succumb to cancer at some point in our lives. So it's not surprising that p53, a protein that helps to prevent the development of malignancies, is the subject of intense scrutiny.
- Kevin M. Ryan and Karen H. Vousden are at the Beatson Institute for Cancer Research, Cancer Research UK Beatson Laboratories, Garscube Estate, Switchback Road, Glasgow G61 1BD, UK.
Correspondence to: e-mail: Email: k.ryan@beatson.gla.ac.uk; Email: k.vousden@beatson.gla.ac.uk
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