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Nature 419, 120-121 (12 September 2002) | doi:10.1038/419120a
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Director, Division of Materials Research
- National Science Foundation
- Arlington, VA
Postdoctoral Research in Functional Genomics
- Harvard School of Public Health, computer science, biology, bioinformatics,
- Boston, MA
DNA repair: Right on target with ubiquitin
Cecile M. Pickart
Abstract
Cellular DNA-repair mechanisms prevent mutations from accumulating, thereby averting defects in cell function. A molecule best known for its role in protein degradation is now shown to have a specific task in DNA repair.
The activity of many of the proteins in our cells depends on the chemical 'labels' that are attached to them. A commonly used label is the ubiquitin molecule, which regulates numerous cellular processes1.
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