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Opinion

Obstacles to biodefence p1

The United States is expected soon to establish its Department of Homeland Security. The precise threats facing the nation are uncertain, but challenges in its preparedness to deal with attacks on health and agriculture are all too obvious.

doi:10.1038/419001a


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News

Geneticists lay foundations for human transcriptome database p3

David Cyranoski

doi:10.1038/419003a


Bush urged to boost funding for physical sciences p3

Geoff Brumfiel

doi:10.1038/419003b


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Naturejobs

Prospects

Setting salaries straight p3

Paul Smaglik

doi:10.1038/nj6902-03a


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News

Name-calling gets stem-cell researcher into hot water p4

Carina Dennis

doi:10.1038/419004a


Dispute over first authorship lands researchers in dock p4

Alison Abbott

doi:10.1038/419004b


Court judgement opens door for study of ancient skeleton p5

Rex Dalton

doi:10.1038/419005a


Diabetes trial stirs debate on safety of xenotransplants p5

Erika Check

doi:10.1038/419005b


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Naturejobs

POSTDOCS

Working your way into industry p5

Karen Kreeger

doi:10.1038/nj6902-05a


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News

Hunt for cosmic rays offers scope for Africa p6

David Adam

doi:10.1038/419006a


Norway sinks ocean carbon study p6

Jim Giles

doi:10.1038/419006b


Call for cash to end the decay of Berlin's great collections p7

Quirin Schiermeier

doi:10.1038/419007a


Gene-bank expansion plan launched at Earth summit p7

Michael Cherry

doi:10.1038/419007b


news in brief p8

doi:10.1038/419008a


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news feature

Correction p9

doi:10.1038/419009a


Homeland-security research: Mission impossible? p10

A new Department of Homeland Security is to be given the task of defending the United States against further terrorist attacks. Geoff Brumfiel outlines the challenges facing its research wing.

Geoff Brumfiel

doi:10.1038/419010a


High-energy astrophysics: Let's catch some rays p12

Particles with hundreds of millions times more energy than those in physicists' accelerators regularly strike the Earth, but no one is sure where they come from. Philip Ball reports on attempts to solve the mystery.

Philip Ball

doi:10.1038/419012a


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Correspondence

French users need European neutrons p15

Big projects may not be popular at present, but policy-makers must think of the future.

and Société Française de la Neutronique

doi:10.1038/419015a


Shared knowledge can combat malaria p15

Yimin Wu and M. John Rogers

doi:10.1038/419015b


Prokaryote taxonomy online: challenges ahead p15

Aharon Oren and Erko Stackebrandt

doi:10.1038/419015c


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Book Reviews

A feast for the mind p17

An introduction to the concept of mind provides plenty of food for thought.

Rosaleen McCarthy reviews Exploring Consciousness/Consciousness by Rita Carter

doi:10.1038/419017a


Predicting extinction risk p18

Richard Frankham reviews Population Viability Analysis edited by Steven R. Beissinger and Dale R. McCullough

doi:10.1038/419018a


Still a round after all this time p18

doi:10.1038/419018b


Shock results p19

Peter Bryant reviews Surprise, Uncertainty and Mental Structures by Jerome Kagan

doi:10.1038/419019a


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concepts

Cell polarity: A chemical compass p21

Only now are we beginning to unravel the mechanisms behind a cell's ability to point in any direction and navigate effectively.

Henry R. Bourne and Orion Weiner

doi:10.1038/419021a


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News and Views

Medicine: RNA as drug and antidote p23

Edward Tuddenham

doi:10.1038/419023a


High-energy physics: The matter with antimatter p24

The Universe is made of matter, not antimatter, and 'CP violation' in particle decays could be the reason. Results from experiments measuring this effect at last confirm the predictions of a 30-year-old theory.

Michael Peskin

doi:10.1038/419024a


100 and 50 years ago p25

doi:10.1038/419025a


Cell biology: Spinning actin to divide p27

When our cells divide, they are cut down the middle by a tightening belt of proteins. New work reveals that the protein filaments in this belt are made from scratch every time.

Shuh Narumiya and Issei Mabuchi

doi:10.1038/419027a


Materials science: Edge effects p28

How do crystal structures terminate at 'flat' surfaces? New developments in electron crystallography mean that the detailed atomic structure of surfaces in complex crystals can be determined — with surprising results.

Michael O'Keeffe

doi:10.1038/419028a


Immunology: The roots of antibody diversity p29

When faced with foreign molecules our antibodies mutate, allowing them to bind to the intruders more strongly. In a story full of surprises, it looks as though the mechanism of mutation has finally been revealed.

Patricia J. Gearhart

doi:10.1038/419029a


Seismology: Stressed to quaking point p32

The Earth's crust can deform catastrophically in earthquakes, but it's difficult to predict exactly what causes such failure. Analysing thousands of small shocks might help us better understand how earthquakes occur.

Chris Marone

doi:10.1038/419032a


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Brief Communications

Anthropology: A lost Neanderthal neonate found p33

A remarkable discovery in a French museum answers some long-standing questions.

Bruno Maureille

doi:10.1038/419033a


Ecology: Effect of British hunting ban on fox numbers p34

Philip J. Baker, Stephen Harris and Charlotte C. Webbon

doi:10.1038/419034a


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Review

The voltage-gated potassium channels and their relatives p35

Gary Yellen

doi:10.1038/nature00978


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Article

Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase p43

Javier Di Noia and Michael S. Neuberger

doi:10.1038/nature00981

See also: News and Views by Gearhart


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Letters to Nature

Spin vector alignment of Koronis family asteroids p49

Stephen M. Slivan

doi:10.1038/nature00993


Collapse and revival of the matter wave field of a Bose–Einstein condensate p51

Markus Greiner, Olaf Mandel, Theodor W. Hänsch and Immanuel Bloch

doi:10.1038/nature00968


The structure and chemistry of the TiO2-rich surface of SrTiO3 (001) p55

Natasha Erdman, Kenneth R. Poeppelmeier, Mark Asta, Oliver Warschkow, Donald E. Ellis and Laurence D. Marks

doi:10.1038/nature01010

See also: News and Views by O'Keeffe


Evidence from the ad 2000 Izu islands earthquake swarm that stressing rate governs seismicity p58

Shinji Toda, Ross S. Stein and Takeshi Sagiya

doi:10.1038/nature00997

See also: News and Views by Marone


Pretender punishment induced by chemical signalling in a queenless ant p61

Thibaud Monnin, Francis L. W. Ratnieks, Graeme R. Jones and Richard Beard

doi:10.1038/nature00932


An ultra-sparse code underliesthe generation of neural sequences in a songbird p65

Richard H. R. Hahnloser, Alexay A. Kozhevnikov and Michale S. Fee

doi:10.1038/nature00974


Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes p70

Karina Del Punta, Trese Leinders-Zufall, Ivan Rodriguez, David Jukam, Charles J. Wysocki, Sonoko Ogawa, Frank Zufall and Peter Mombaerts

doi:10.1038/nature00955


The ELF4 gene controls circadian rhythms and flowering time in Arabidopsis thaliana p74

Mark R. Doyle, Seth J. Davis, Ruth M. Bastow, Harriet G. McWatters, László Kozma-Bognár, Ferenc Nagy, Andrew J. Millar and Richard M. Amasino

doi:10.1038/nature00954


Protective role of phospholipid oxidation products in endotoxin-induced tissue damage p77

Valery N. Bochkov, Alexandra Kadl, Joakim Huber, Florian Gruber, Bernd R. Binder and Norbert Leitinger

doi:10.1038/nature01023


Actin dynamics in the contractile ring during cytokinesis in fission yeast p82

Robert J. Pelham, Jr and Fred Chang

doi:10.1038/nature00999

See also: News and Views by Narumiya & Mabuchi


The U1 snRNP protein U1C recognizes the 5' splice site in the absence of base pairing p86

Hansen Du and Michael Rosbash

doi:10.1038/nature00947


RNA aptamers as reversible antagonists of coagulation factor IXa p90

Christopher P. Rusconi, Elizabeth Scardino, Juliana Layzer, George A. Pitoc, Thomas L. Ortel, Dougald Monroe and Bruce A. Sullenger

doi:10.1038/nature00963

See also: News and Views by Tuddenham


corrigendum: Sub-ångstrom resolution using aberration corrected electron optics p94

P. E. Batson, N. Dellby and O. L. Krivanek

doi:10.1038/nature01058


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New on the Market

Putting the C into PCR p95

A round-up of thermocyclers and other PCR-related kit.

doi:10.1038/419095a


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