Table of contents
Volume 418 Number 6899 pp3-802
Naturejobs
ProspectsA decisive effort? p3
Paul Smaglik
doi:10.1038/nj6899-03a
Careers and Recruitment
Small world, big opportunities p4
At last nanotechnology is moving from the realm of hype and hope into the real world, with jobs and funding appearing on both sides of the Atlantic. Paul Smaglik considers the options.
Paul Smaglik
doi:10.1038/nj6899-04a
Breaking down biological borders p7
Opportunities in nanotechnology are opening up in Japan — especially for young researchers willing to cooperate across disciplines, says Robert Triendl.
Robert Triendl
doi:10.1038/nj6899-07a
Opinion
Slowdown will undermine reform p709
France's new research minister faces tough challenges in introducing much-needed changes into the research system. Her difficulties are compounded by impending budgetary constraints.
doi:10.1038/418709a
Save starry nights p709
Cities should stop lighting up the heavens.
doi:10.1038/418709b
News
Senators attack Pentagon over weak state of defence research p711
Geoff Brumfiel
doi:10.1038/418711a
Online cheats leave Asian students facing paper exam p711
Erika Check
doi:10.1038/418711b
French minister plans shake-up for research p712
Declan Butler and Sally Goodman
doi:10.1038/418712a
Scientists seek safety in secrets of the soundbite p712
David Adam
doi:10.1038/418712b
Climate model under fire as rains fail India p713
K. S. Jayaraman
doi:10.1038/418713a
Top projects suffer as medical funding falters p714
Natasha McDowell
doi:10.1038/418714a
Lessons in research aim to win pupils over to science p714
Quirin Schiermeier
doi:10.1038/418714b
news feature
Ocean policy: Troubled waters p718
The oceans around the United States suffer from overfishing and pollution, but current government regulatory structures only hamper attempts to fix these problems. Can two high-level commissions put things right? Mark Schrope investigates.
Mark Schrope
doi:10.1038/418718a
High speed biomechanics: Caught on camera p721
By recording animal movements that are too fast for the human eye to follow, high-speed digital video is transforming studies at the interface of biomechanics, neuroscience and evolutionary biology. Rex Dalton reports.
Rex Dalton
doi:10.1038/418721a
Correspondence
Plant mathematics and Fibonacci's flowers p723
Asymmetric cell division is an intriguing but unlikely explanation for the patterns of leaves.
Andrew J. Fleming
doi:10.1038/418723a
Macroecology is distinct from biogeography p723
Tim M. Blackburn and Kevin J. Gaston
doi:10.1038/418723b
The search for general principles in ecology p723
Pablo A. Marquet
doi:10.1038/418723c
Book Reviews
Encounters with a dark lady p725
An insight into one of the scientists who determined the structure of DNA.
David Blow reviews Rosalind Franklin: The Dark Lady of DNA by Brenda Maddox
doi:10.1038/418725a
New in paperback p726
doi:10.1038/418726a
Record of a revolution p726
Adrian Johns reviews An Annotated Census of Copernicus' De revolutionibus: (Nuremberg, 1543 and Basel, 1566) by Owen Gingerich
doi:10.1038/418726b
Eco-physiology comes of age p727
John Speakman reviews Physiological Ecology of Vertebrates: A View from Energetics by Brian K. McNab
doi:10.1038/418727a
concepts
Protein-misfolding diseases: Getting out of shape p729
Christopher M. Dobson
doi:10.1038/418729a
News and Views
Malaria: Mass tool for diagnosis p731
Efficient and sensitive methods to determine whether, and to what extent, a person is infected with malaria should help to improve treatment. A high-tech approach, using mass spectrometry, may be the answer.
Matthias Mann
doi:10.1038/418731a
Cell motility: Braking WAVEs p732
When cells move, they alter their internal skeleton to push membrane out at the front and pull it in at the back. New work fills in some of the gaps in our knowledge of how this process is regulated.
Giles O. C. Cory and Anne J. Ridley
doi:10.1038/418732a
Superconductivity: Mind the double gap p733
Magnesium diboride superconducts at an unexpectedly high temperature. It is now clear that the material also has an unusual, but long-sought, 'double energy gap' structure that influences its superconductivity.
Warren Pickett
doi:10.1038/418733a
Signal transduction: Positive feedback from coffee p734
Caffeine acts on our nerve cells to wake us up. It turns out that it does so through a molecular signalling pathway that involves a positive feedback loop, boosting caffeine's effects from inside the cell.
Jean-Marie Vaugeois
doi:10.1038/418734a
Earth science: Breaking plates p736
Seismic images suggest that oceanic plates in the northwest Pacific broke apart as they descended into Earth's mantle. That might explain the high magma output of some volcanoes in the region, and why others are extinct.
J. Huw Davies
doi:10.1038/418736a
Developmental biology: Signalling legacies p737
Until now, the signals that control the development of the legs in insects and vertebrates have been thought to be different. But new work reveals similarities, which might have evolutionary implications.
Richard S. Mann and Fernando Casares
doi:10.1038/418737a
High-energy physics: Vote for Little Higgs p738
Alison Wright
doi:10.1038/418738a
Condensed matter: Scratching the Bose surface p739
There are two distinct types of particles in nature: fermions and bosons. But it seems bosons may assume similar characteristics to fermion systems in the low-temperature regime typical of Bose–Einstein condensation.
Subir Sachdev
doi:10.1038/418739a
Physiology: Muscle regulator goes the distance p740
Richard Turner
doi:10.1038/418740a
Brief Communications
Materials: Surprising strength of silkworm silk p741
Silk fibres produced by artificial reeling are superior to those that are spun naturally.
Zhengzhong Shao and Fritz Vollrath
doi:10.1038/418741a
First paragraph | Full Text | PDF (67K)
Malaria: Thermoregulation in a parasite's life cycle p742
Jun Fang and Thomas F. McCutchan
doi:10.1038/418742a
First paragraph | Full Text | PDF (52K)
Article
A physical map of the mouse genome p743
Simon G. Gregory, Mandeep Sekhon, Jacqueline Schein, Shaying Zhao, Kazutoyo Osoegawa, Carol E. Scott, Richard S. Evans, Paul W. Burridge, Tony V. Cox, Christopher A. Fox, Richard D. Hutton, Ian R. Mullenger, Kimbly J. Phillips, James Smith, Jim Stalker, Glen J. Threadgold, Ewan Birney, Kristine Wylie, Asif Chinwalla, John Wallis, LaDeana Hillier, Jason Carter, Tony Gaige, Sara Jaeger, Colin Kremitzki, Dan Layman, Jason Maas, Rebecca McGrane, Kelly Mead, Rebecca Walker, Steven Jones, Michael Smith, Jennifer Asano, Ian Bosdet, Susanna Chan, Suganthi Chittaranjan, Readman Chiu, Chris Fjell, Dan Fuhrmann, Noreen Girn, Catharine Gray, Ran Guin, Letticia Hsiao, Martin Krzywinski, Reta Kutsche, Soo Sen Lee, Carrie Mathewson, Candice McLeavy, Steve Messervier, Steven Ness, Pawan Pandoh, Anna-Liisa Prabhu, Parvaneh Saeedi, Duane Smailus, Lorraine Spence, Jeff Stott, Sheryl Taylor, Wesley Terpstra, Miranda Tsai, Jill Vardy, Natasja Wye, George Yang, Sofiya Shatsman, Bola Ayodeji, Keita Geer, Getahun Tsegaye, Alla Shvartsbeyn, Elizabeth Gebregeorgis, Margaret Krol, Daniel Russell, Larry Overton, Joel A. Malek, Mike Holmes, Michael Heaney, Jyoti Shetty, Tamara Feldblyum, William C. Nierman, Joseph J. Catanese, Tim Hubbard, Robert H. Waterston, Jane Rogers, Pieter J. de Jong, Claire M. Fraser, Marco Marra, John D. McPherson and David R. Bentley
doi:10.1038/nature00957
Abstract | Full Text | PDF (484K) | Supplementary information
Letters to Nature
Macroscopically ordered state in an exciton system p751
L. V. Butov, A. C. Gossard and D. S. Chemla
doi:10.1038/nature00943
First paragraph | Full Text | PDF (271K)
Long-range transport in excitonic dark states in coupled quantum wells p754
D. Snoke, S. Denev, Y. Liu, L. Pfeiffer and K. West
doi:10.1038/nature00940
First paragraph | Full Text | PDF (278K)
The origin of the anomalous superconducting properties of MgB2 p758
Hyoung Joon Choi, David Roundy, Hong Sun, Marvin L. Cohen and Steven G. Louie
doi:10.1038/nature00898
First paragraph | Full Text | PDF (519K)
See also: News and Views by Pickett
The influence of a chemical boundary layer on the fixity, spacing and lifetime of mantle plumes p760
A. Mark Jellinek and Michael Manga
doi:10.1038/nature00979
First paragraph | Full Text | PDF (235K)
Seismic evidence for catastrophic slab loss beneath Kamchatka p763
Vadim Levin, Nikolai Shapiro, Jeffrey Park and Michael Ritzwoller
doi:10.1038/nature00973
First paragraph | Full Text | PDF (494K)
See also: News and Views by Davies
A primitive fish close to the common ancestor of tetrapods and lungfish p767
Min Zhu and Xiaobo Yu
doi:10.1038/nature00871
First paragraph | Full Text | PDF (504K) | Supplementary information
Increasing dominance of large lianas in Amazonian forests p770
Oliver L. Phillips, Rodolfo Vásquez Martínez, Luzmila Arroyo, Timothy R. Baker, Timothy Killeen, Simon L. Lewis, Yadvinder Malhi, Abel Monteagudo Mendoza, David Neill, Percy Núñez Vargas, Miguel Alexiades, Carlos Cerón, Anthony Di Fiore, Terry Erwin, Anthony Jardim, Walter Palacios, Mario Saldias and Barbara Vinceti
doi:10.1038/nature00926
First paragraph | Full Text | PDF (280K) | Supplementary information
Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine p774
Maria Lindskog, Per Svenningsson, Laura Pozzi, Yong Kim, Allen A. Fienberg, James A. Bibb, Bertil B. Fredholm, Angus C. Nairn, Paul Greengard and Gilberto Fisone
doi:10.1038/nature00817
First paragraph | Full Text | PDF (326K)
See also: News and Views by Vaugeois
Sperm from neonatal mammalian testes grafted in mice p778
Ali Honaramooz, Amy Snedaker, Michele Boiani, Hans Schöler, Ina Dobrinski and Stefan Schlatt
doi:10.1038/nature00918
First paragraph | Full Text | PDF (372K)
Distalization of the Drosophila leg by graded EGF-receptor activity p781
Gerard Campbell
doi:10.1038/nature00971
First paragraph | Full Text | PDF (460K) | Supplementary information
See also: News and Views by Mann & Casares
Synthetic GPI as a candidate anti-toxic vaccine in a model of malaria p785
Louis Schofield, Michael C. Hewitt, Krystal Evans, Mary-Anne Siomos and Peter H. Seeberger
doi:10.1038/nature00937
First paragraph | Full Text | PDF (262K) | Supplementary information
Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck p790
Sharon Eden, Rajat Rohatgi, Alexandre V. Podtelejnikov, Matthias Mann and Marc W. Kirschner
doi:10.1038/nature00859
First paragraph | Full Text | PDF (310K)
See also: News and Views by Cory & Ridley
Modulation of an RNA-binding protein by abscisic-acid-activated protein kinase p793
Jiaxu Li, Toshinori Kinoshita, Sona Pandey, Carl K.-Y. Ng, Steven P. Gygi, Ken-ichiro Shimazaki and Sarah M. Assmann
doi:10.1038/nature00936
First paragraph | Full Text | PDF (1,367K) | Supplementary information
Transcriptional co-activator PGC-1
drives the formation of slow-twitch muscle fibres p797
Jiandie Lin, Hai Wu, Paul T. Tarr, Chen-Yu Zhang, Zhidan Wu, Olivier Boss, Laura F. Michael, Pere Puigserver, Eiji Isotani, Eric N. Olson, Bradford B. Lowell, Rhonda Bassel-Duby and Bruce M. Spiegelman
doi:10.1038/nature00904
First paragraph | Full Text | PDF (306K)
See also: News and Views by Turner
erratum: A new hominid from the Upper Miocene of Chad, Central Africa p801
Michel Brunet, Franck Guy, David Pilbeam, Hassane Taisso Mackaye, Andossa Likius, Djimdoumalbaye Ahounta, Alain Beauvilain, Cécile Blondel, Hervé Bocherens, Jean-Renaud Boisserie, Louis De Bonis, Yves Coppens, Jean Dejax, Christiane Denys, Philippe Duringer, Véra Eisenmann, Gongdibé Fanone, Pierre Fronty, Denis Geraads, Thomas Lehmann, Fabrice Lihoreau, Antoine Louchart, Adoum Mahamat, Gildas Merceron, Guy Mouchelin, Olga Otero, Pablo Pelaez Campomanes, Marcia Ponce De Leon, Jean-Claude Rage, Michel Sapanet, Mathieu Schuster, Jean Sudre, Pascal Tassy, Xavier Valentin, Patrick Vignaud, Laurent Viriot, Antoine Zazzo and Christoph Zollikofer
doi:10.1038/nature01005
New on the Market
Degrees of separation p802
The first of two tranches of new chromatography products.
doi:10.1038/418802a