Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Longevity

Don't hold your breath

Nature volume 418, pages 287–288 (2002)Cite this article

In some organisms a reduced-calorie diet increases lifespan. Conventional thinking about the mechanism involved now comes under question from the results of experiments with yeast.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1

DAVID SCHARF/SPL

References

  1. McCay, C., Crowell, M. & Maynard, L. J. Nutr. 10, 63–79 (1935).

    Article  CAS  Google Scholar 

  2. Finch, C. E. (ed.) in Longevity, Senescence, and the Genome 504–536 (Univ. Chicago Press, 1990).

  3. Lin, S.-J et al. Nature 418, 344–348 (2002).

    Article  CAS  ADS  Google Scholar 

  4. Roth, G. S., Ingram, D. K. & Lane, M. A. J. Am. Geriatr. Soc. 47, 896–903 (1999).

    Article  CAS  Google Scholar 

  5. Masoro, E. J. Exp. Gerontol. 35, 299–305 (2000).

    Article  CAS  Google Scholar 

  6. Lin, S.-J, Defossez, P. A. & Guarente, L. Science 289, 2126–2128 (2000).

    Article  CAS  ADS  Google Scholar 

  7. DeRisi, J. L., Iyer, V. R. & Brown, P. O. Science 278, 680–686 (1997).

    Article  CAS  ADS  Google Scholar 

  8. Blom, J., De Mattos, M. J. & Grivell, L. A. Appl. Environ. Microbiol. 66, 1970–1973 (2000).

    Article  CAS  Google Scholar 

  9. Sohal, R. S. & Weindruch, R. Science 273, 59–63 (1996).

    Article  CAS  ADS  Google Scholar 

  10. Finkel, T. & Holbrook, N. J. Nature 408, 239–247 (2000).

    Article  CAS  ADS  Google Scholar 

  11. Kumar, A. et al. Genes Dev. 16, 707–719 (2002).

    Article  CAS  Google Scholar 

  12. Weindruch, R., Kayo, T., Lee, C. K. & Prolla, T. A. J. Nutr. 131, 918S–923S (2001).

    Article  CAS  Google Scholar 

  13. Tissenbaum, H. A. & Guarente, L. Nature 410, 227–230 (2001).

    Article  CAS  ADS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Genetics, and the Department of Molecular Biology, Harvard Medical School, Massaschusetts General Hospital, Boston, 02114, Massachusetts, USA

    Siu Sylvia Lee & Gary Ruvkun

Authors
  1. Siu Sylvia Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gary Ruvkun
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Siu Sylvia Lee.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lee, S., Ruvkun, G. Don't hold your breath. Nature 418, 287–288 (2002). https://doi.org/10.1038/418287a

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/418287a

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing