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Nature 417, 501-502 (30 May 2002) | doi:10.1038/417501a
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Biochemical Pharmacologist
- Eisai London Research Laboratories Ltd
- Hatfield, United Kingdom
Developer - Variation (Bioinformatician)
- European Bioinformatics Institute (EBI)
- Cambridge CB10 1SD United Kingdom
Ion channels: An open and shut case
Maria Schumacher & John P. Adelman
Abstract
Most ion channels open and close — they are 'gated' — in response to cues in their environment. A crystal structure of a Ca2+-gated K+-ion channel provides insight into how gating works.
Nervous systems are built for speed, using electrical signals that are propagated by the activities of ion channels. Two responsibilities are incumbent on these membrane-spanning proteins.
- Maria Schumacher is in the Department of Biochemistry and Molecular Biology, and John P. Adelman is at the Vollum Institute, Oregon Health and Sciences University, Portland, Oregon 97201, USA
Correspondence to: e-mail: Email: adelman@ohsu.edu
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