Naturejobs

Talent tug-of-war p3

Paul Smaglik

doi:10.1038/nj6887-03a

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Training programmes with vision p5

Karen Kreeger

doi:10.1038/nj6887-05a

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doi:10.1038/nj6887-99a

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Opinion

South Africa's new landscape p365

Despite progress towards racial integration, proposals to rationalize by merging universities are being attacked as threats to the identity of some institutions. There is another way forward that deserves to be considered.

doi:10.1038/417365a

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Nature and the developing world p365

Nature's publishers are making their journals freely available to the world's poorest countries.

doi:10.1038/417365b

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News

Bell Labs launches inquiry into allegations of data duplication p367

Geoff Brumfiel

doi:10.1038/417367a

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Public ponders biotech issues p368

Quirin Schiermeier

doi:10.1038/417368a

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US 'overspent' on collider project p368

Geoff Brumfiel

doi:10.1038/417368b

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Chemists synthesize a single naming system p369

David Adam

doi:10.1038/417369a

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NASA's critics demand a few more steps into space p369

Tony Reichhardt

doi:10.1038/417369b

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Think-tank calls for an end to DNA deception p370

David Adam

doi:10.1038/417370a

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Biotech firm's accounts scrutinized p370

Erika Check

doi:10.1038/417370b

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Canadian collaboration aims to protect tribes p371

Rex Dalton

doi:10.1038/417371a

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Harvard mourns loss of popular evolutionary thinker p371

Erika Check

doi:10.1038/417371b

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news in brief p372

doi:10.1038/417372a

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news feature

Evolutionary genetics: All genomes great and small p374

Chromosome size and number can vary widely between closely related organisms. This poses a challenge for the evolutionary geneticists who are trying to make sense of genome structure, says Jonathan Knight.

Jonathan Knight

doi:10.1038/417374a

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South Africa: The rainbow academic nation p377

South Africa's higher-education system was designed by the architects of apartheid. So why are today's academics resisting attempts to reform it? Michael Cherry investigates.

Michael Cherry

doi:10.1038/417377a

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Correspondence

Restricting genome data won't stop bioterrorism p379

Release of sequence information is necessary to aid defence against these pathogens.

Timothy D. Read and Julian Parkhill

doi:10.1038/417379a

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What's in a name? In the Middle East, everything p379

Knut Rognes

doi:10.1038/417379b

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Foundation's funding p379

Heather E. Kowalski

doi:10.1038/417379c

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Book Reviews

Science is a computer program p381

If complexity arises from simple rules, should we rethink how to do science?

John L. Casti reviews A New Kind of Science by Stephen Wolfram

doi:10.1038/417381a

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Optics for the real world p382

Chris Dainty reviews Classical Optics and its Applications by Masud Mansuripur

doi:10.1038/417382a

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Swimming lessons p383

Angus I. Lamond reviews Molecular Biology of the Cell, 4th edition by Bruce Alberts, Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts and Peter Walter

doi:10.1038/417383a

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concepts

Equilibrium: In the balance p385

Ivar Ekeland

doi:10.1038/417385a

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News and Views

Medicine: Anti-malarial mosquitoes? p387

Researchers have generated genetically altered mosquitoes with a reduced ability to transmit the malaria parasite in the lab. This is an important proof of principle, but there's still a long road ahead.

Gareth J. Lycett and Fotis C. Kafatos

doi:10.1038/417387a

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Polymer chemistry: Swell gels p388

Linked chains of polymers can form hydrogels, whose properties are attractive for biomedical applications. It seems that the molecular arrangement of the polymer ingredients is central to hydrogel performance.

Jindich Kopeek

doi:10.1038/417388a

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100 and 50 years ago p389

doi:10.1038/417389a

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Circadian rhythms: A gut feeling for time p391

Many body functions keep a daily rhythm, maintained by a central clock in the brain. But how does the clock communicate with the rest of the body? The small protein prokineticin 2 looks well placed to be the messenger.

Michael H. Hastings

doi:10.1038/417391a

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Applied physics: Making sense of magnetic fields p392

Although there have been dramatic advances in generating enormous magnetic fields, measuring these fields remains difficult. A non-metallic sensor based on a silver chalcogenide looks promising.

Yeong-Ah Soh and Gabriel Aeppli

doi:10.1038/417392a

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Kidney function: Gateway to a long life? p393

A molecule has been identified that seems to regulate the levels of uric acid in humans. The discovery has implications for understanding diseases such as gout and may even shed light on human longevity.

Matthias A. Hediger

doi:10.1038/417393a

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Daedalus: Vegetarian meat p395

Daedalus is extending the idea of the 'augmented egg', described last week. He wants to produce plastic eggs in which chicks could grow to adulthood without ever becoming conscious.

David Jones

doi:10.1038/417395a

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Obituary: Victor F. Weisskopf (1908–2002) p396

Kurt Gottfried

doi:10.1038/417396a

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Brief Communications

Crystal topology: A Möbius strip of single crystals p397

A crystalline ribbon of niobium and selenium can be coaxed into a novel topology.

Satoshi Tanda, Taku Tsuneta, Yoshitoshi Okajima, Katsuhiko Inagaki, Kazuhiko Yamaya and Noriyuki Hatakenaka

doi:10.1038/417397a

First paragraph | Full Text | PDF (95K)

Endosymbiotic bacteria: GroEL buffers against deleterious mutations p398

Mario A. Fares, Mario X. Ruiz-González, Andrés Moya, Santiago F. Elena and Eladio Barrio

doi:10.1038/417398a

First paragraph | Full Text | PDF (38K)

Analysis

Comparative assessment of large-scale data sets of protein–protein interactions p399

Christian von Mering, Roland Krause, Berend Snel, Michael Cornell, Stephen G. Oliver, Stanley Fields and Peer Bork

doi:10.1038/nature750

Abstract | Full Text | PDF (164K) | Supplementary information

Articles

Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus p405

Michelle Y. Cheng, Clayton M. Bullock, Chuanyu Li, Alex G. Lee, Jason C. Bermak, James Belluzzi, David R. Weaver, Frances M. Leslie and Qun-Yong Zhou

doi:10.1038/417405a

Abstract | Full Text | PDF (450K) | Supplementary information

See also: News and Views by Hastings

Adaptation in the chemotactic guidance of nerve growth cones p411

Guo-li Ming, Scott T. Wong, John Henley, Xiao-bing Yuan, Hong-jun Song, Nicholas C. Spitzer and Mu-ming Poo

doi:10.1038/nature745

Abstract | Full Text | PDF (421K)

Letters to Nature

Thickness constraints on the icy shells of the galilean satellites from a comparison of crater shapes p419

Paul M. Schenk

doi:10.1038/417419a

First paragraph | Full Text | PDF (235K)

Megagauss sensors p421

A. Husmann, J. B. Betts, G. S. Boebinger, A. Migliori, T. F. Rosenbaum and M.-L. Saboungi

doi:10.1038/417421a

First paragraph | Full Text | PDF (2,449K)

See also: News and Views by Soh & Aeppli

Rapidly recovering hydrogel scaffolds from self-assembling diblock copolypeptide amphiphiles p424

Andrew P. Nowak, Victor Breedveld, Lisa Pakstis, Bulent Ozbas, David J. Pine, Darrin Pochan and Timothy J. Deming

First paragraph | Full Text | PDF (270K) | Supplementary information

See also: News and Views by Kopeek

Low slip rates and long-term preservation of geomorphic features in Central Asia p428

Ralf Hetzel, Samuel Niedermann, Mingxin Tao, Peter W. Kubik, Susan Ivy-Ochs, Bo Gao and Manfred R. Strecker

doi:10.1038/417428a

First paragraph | Full Text | PDF (523K) | Supplementary information

Recovery of 16S ribosomal RNA gene fragments from ancient halite p432

Steven A. Fish, Thomas J. Shepherd, Terry J. McGenity and William D. Grant

doi:10.1038/417432a

First paragraph | Full Text | PDF (479K)

Coexistence and relative abundance in forest trees p437

Colleen K. Kelly and Michael G. Bowler

doi:10.1038/417437a

First paragraph | Full Text | PDF (222K)

Host-plant adaptation drives the parallel evolution of reproductive isolation p440

Patrik Nosil, Bernard J. Crespi and Cristina P. Sandoval

doi:10.1038/417440a

First paragraph | Full Text | PDF (186K)

Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation p443

Christelle Forcet, Elke Stein, Laurent Pays, Véronique Corset, Fabien Llambi, Marc Tessier-Lavigne and Patrick Mehlen

doi:10.1038/nature748

First paragraph | Full Text | PDF (338K)

Molecular identification of a renal urate–anion exchanger that regulates blood urate levels p447

Atsushi Enomoto, Hiroaki Kimura, Arthit Chairoungdua, Yasuhiro Shigeta, Promsuk Jutabha, Seok Ho Cha, Makoto Hosoyamada, Michio Takeda, Takashi Sekine, Takashi Igarashi, Hirotaka Matsuo, Yuichi Kikuchi, Takashi Oda, Kimiyoshi Ichida, Tatsuo Hosoya, Kaoru Shimokata, Toshimitsu Niwa, Yoshikatsu Kanai and Hitoshi Endou

doi:10.1038/nature742

First paragraph | Full Text | PDF (329K) | Supplementary information

See also: News and Views by Hediger

Transgenic anopheline mosquitoes impaired in transmission of a malaria parasite p452

Junitsu Ito, Anil Ghosh, Luciano A. Moreira, Ernst A. Wimmer and Marcelo Jacobs-Lorena

doi:10.1038/417452a

First paragraph | Full Text | PDF (260K)

See also: News and Views by Lycett & Kafatos

HDAC6 is a microtubule-associated deacetylase p455

Charlotte Hubbert, Amaris Guardiola, Rong Shao, Yoshiharu Kawaguchi, Akihiro Ito, Andrew Nixon, Minoru Yoshida, Xiao-Fan Wang and Tso-Pang Yao

doi:10.1038/417455a

First paragraph | Full Text | PDF (302K)

Comparison of the genomes of two Xanthomonas pathogens with differing host specificities p459

A. C. R. da Silva, J. A. Ferro, F. C. Reinach, C. S. Farah, L. R. Furlan, R. B. Quaggio, C. B. Monteiro-Vitorello, M. A. Van Sluys, N. F. Almeida, L. M. C. Alves, A. M. do Amaral, M. C. Bertolini, L. E. A. Camargo, G. Camarotte, F. Cannavan, J. Cardozo, F. Chambergo, L. P. Ciapina, R. M. B. Cicarelli, L. L. Coutinho, J. R. Cursino-Santos, H. El-Dorry, J. B. Faria, A. J. S. Ferreira, R. C. C. Ferreira, M. I. T. Ferro, E. F. Formighieri, M. C. Franco, C. C. Greggio, A. Gruber, A. M. Katsuyama, L. T. Kishi, R. P. Leite, E. G. M. Lemos, M. V. F. Lemos, E. C. Locali, M. A. Machado, A. M. B. N. Madeira, N. M. Martinez-Rossi, E. C. Martins, J. Meidanis, C. F. M. Menck, C. Y. Miyaki, D. H. Moon, L. M. Moreira, M. T. M. Novo, V. K. Okura, M. C. Oliveira, V. R. Oliveira, H. A. Pereira, A. Rossi, J. A. D. Sena, C. Silva, R. F. de Souza, L. A. F. Spinola, M. A. Takita, R. E. Tamura, E. C. Teixeira, R. I. D. Tezza, M. Trindade dos Santos, D. Truffi, S. M. Tsai, F. F. White, J. C. Setubal and J. P. Kitajima

doi:10.1038/417459a

First paragraph | Full Text | PDF (180K) | Supplementary information

The catalytic pathway of horseradish peroxidase at high resolution p463

Gunnar I. Berglund, Gunilla H. Carlsson, Andrew T. Smith, Hanna Szöke, Anette Henriksen and Janos Hajdu

doi:10.1038/417463a

First paragraph | Full Text | PDF (626K) | Supplementary information

retraction: Directed evolution of new catalytic activity using the /-barrel scaffold p468

M. M. Altamirano, J. M. Blackburn, C. Aguayo and A. R. Fersht

doi:10.1038/417468a

Full Text | PDF (61K)

New on the Market

Kit and kits for proteomics, genomics p469

Imaging, thermocycling, data mining, genotyping and cloning.

doi:10.1038/417469a

Full Text | PDF (101K)