Naturejobs

A basic problem p3

Paul Smaglik

doi:10.1038/nj6886-03a

Full Text | PDF (75K)

Boston: A magnetic hub p4

Paul Smaglik

doi:10.1038/nj6886-04a

Full Text | PDF (187K)

Opinion

Collaboration in extremis p207

Conditions could not be worse for collaborative science between Israel and its neighbours. But the interests of politics, regional development and science all favour such collaborations. Institutions as well as individuals should promote them.

doi:10.1038/417207a

Full Text | PDF (44K)

News

Science collaboration stymied by relentless Middle East conflict p209

Declan Butler

doi:10.1038/417209a

Full Text | PDF (180K)

Plan hatched to double NSF budget p209

Geoff Brumfiel

doi:10.1038/417209b

Full Text | PDF (180K)

Warhead-saving arms pact gets lukewarm reception p210

Geoff Brumfiel

doi:10.1038/417210a

Full Text | PDF (64K)

Computer revives Bamiyan Buddha p210

Quirin Schiermeier

doi:10.1038/417210b

Full Text | PDF (64K)

Geneticists lay plans for rationalized rodents p211

Alison Abbott

doi:10.1038/417211a

Full Text | PDF (102K)

Unrest leads reformer to quit Seoul university's top job p211

David Cyranoski

doi:10.1038/417211b

Full Text | PDF (102K)

Utah law triggers university row over concealed weapons p212

Rex Dalton

doi:10.1038/417212a

Full Text | PDF (113K)

Deep-sea nuggets prove irresistible to Indian miners p212

K. S. Jayaraman

doi:10.1038/417212b

Full Text | PDF (113K)

Reality TV show recreates famed social study p213

David Adam

doi:10.1038/417213a

Full Text | PDF (125K)

Jefferson's descendants continue to deny slave link p213

Erika Check

doi:10.1038/417213b

Full Text | PDF (125K)

news in brief p214

doi:10.1038/417214a

Full Text | PDF (127K)

news feature

Stephen Wolfram: What kind of science is this? p216

Mathematical prodigy Stephen Wolfram has laboured for a decade on what he claims is a revolutionary book. Jim Giles meets a supremely confident scientific loner, but finds expert opinion on the work's merits divided.

Jim Giles

doi:10.1038/417216a

Full Text | PDF (704K)

Chemistry and art: St Luke's new coat p219

By combining chemical analyses with digital image reconstruction, it is possible to complete virtual restorations of deteriorated paintings. Celeste Biever considers the technology's potential.

Celeste Biever

doi:10.1038/417219a

Full Text | PDF (244K)

Correspondence

Better communication is in everyone's interests p221

Scientists will find it's worth making the effort to explain what they're doing to the public.

Elizabeth J. Tait

doi:10.1038/417221a

Full Text | PDF (48K)

Boycott of Israel? It worked for South Africa p221

Steven Rose and Hilary Rose

doi:10.1038/417221b

Full Text | PDF (48K)

Palestinian scientists are already restricted p221

Ahmed Abbes, Mikhael Balabane, Emmanuel Farjoun, Michael Harris, Raphael Rouquier and Pierre Schapira

doi:10.1038/417221c

Full Text | PDF (48K)

Efforts to build bridges in the Middle East p222

Marc Mangel

doi:10.1038/417222a

Full Text | PDF (38K)

Taxonomists need better access to published data p222

Donat Agosti and Norman F. Johnson

doi:10.1038/417222b

Full Text | PDF (38K)

Advocacy and analysis p222

Carl Mitcham

doi:10.1038/417222c

Full Text | PDF (38K)

Specimen collecting is still vital for research p222

Angelo Capparella

doi:10.1038/417222d

Full Text | PDF (38K)

Book Reviews

A popular evolution p223

An authoritative introduction to the history of life from a respected theorist.

Mark Ridley reviews What Evolution Is by Ernst Mayr

doi:10.1038/417223a

Full Text | PDF (113K)

Tuning in to radio galaxies p224

K. I. Kellermann reviews The Physics of Extragalactic Radio Sources by David S. De Young

doi:10.1038/417224a

Full Text | PDF (107K)

Exactly the same but different p224

Justine Burley reviews The Secret by Eva Hoffman

doi:10.1038/417224b

Full Text | PDF (107K)

Science in culture p225

Alison Abbott reviews

doi:10.1038/417225a

Full Text | PDF (55K)

concepts

Centromeres: Selfish drivers p227

Steven Henikoff and Harmit S. Malik

doi:10.1038/417227a

Full Text | PDF (68K)

News and Views

Biodiversity: Thinking big in ecology p229

A conjunction of ecology and evolution has recently produced offspring — the discipline known as macroecology. This bonny baby takes a large-scale view of the world and finds it full of contradictions.

Sean Nee

doi:10.1038/417229a

Full Text | PDF (111K)

Physical chemistry: Acids caught in the act p230

Using infrared spectroscopy, the separate stages of the dissociation of hydrogen chloride molecules on an ice surface have been revealed. The formation of hydrogen bonds seems to be a decisive factor in the process.

Samuel Leutwyler

doi:10.1038/417230a

Full Text | PDF (107K)

Amyloid diseases: Small drugs lead the attack p231

Many human disorders — a well-known example being Alzheimer's disease — are characterized by the misfolding and aggregation of key proteins. New small-molecule drugs may help to destabilize these aggregates.

Leslie Iversen

doi:10.1038/417231a

Full Text | PDF (145K)

100 and 50 years ago p231

doi:10.1038/417231b

Full Text | PDF (145K)

Planetary science: A wet and altered Mars p234

Has Mars always been cold and dry or was it once warm and wet? Reanalysis of spacecraft data reveals a signature from the surface rocks that indicates their composition has been altered in the presence of water.

John F. Mustard

doi:10.1038/417234a

Full Text | PDF (114K)

Cancer: New-age tumour suppressors p235

The discovery of a gene that is inactivated in stomach cancers illustrates the value of mouse models for finding tumour-suppressor genes that are switched off by mechanisms other than mutation.

Allan Balmain

doi:10.1038/417235a

Full Text | PDF (54K)

Materials science: Cooking up tougher ceramics p237

Ceramics based on silicon nitride have already proved their worth in terms of engineering applications. A technique that allows greater control over their final structure opens up yet further possibilities.

D. P. Thompson

doi:10.1038/417237a

Full Text | PDF (45K)

Ion channels: How to be desensitized p238

The various functional states of glutamate receptors control much of the brain's neuronal activity. Our understanding of how one of those states — desensitization — occurs has taken a leap forward.

Christian Rosenmund and Michael Mansour

doi:10.1038/417238a

Full Text | PDF (462K)

Developmental biology: Signalling polarity p239

Cell signalling pathways triggered by Wnt proteins control gene expression and cell behaviour, especially during development. Work on frogs reveals another specific role for these proteins, and the signalling involved.

Randall T. Moon and Kavita Shah

doi:10.1038/417239a

Full Text | PDF (302K)

Daedalus: Augmented eggs p240

David Jones

doi:10.1038/417240a

Full Text | PDF (45K)

Brief Communications

Neurology: An ancient sensory organ in crocodilians p241

Waiting alligators can detect silent ripples in the water even in total darkness.

Daphne Soares

doi:10.1038/417241a

First paragraph | Full Text | PDF (266K)

Acidic deposition: Decline in mobilization of toxic aluminium p242

Sheila M. Palmer and Charles T. Driscoll

doi:10.1038/417242a

First paragraph | Full Text | PDF (137K)

Caenorhabditis elegans: Plague bacteria biofilm blocks food intake p243

Creg Darby, Jennifer W. Hsu, Nafisa Ghori and Stanley Falkow

doi:10.1038/417243a

First paragraph | Full Text | PDF (131K)

Phylogeny: A non-hyperthermophilic ancestor for Bacteria p244

Céline Brochier and Hervé Philippe

doi:10.1038/417244a

First paragraph | Full Text | PDF (47K)

Articles

Mechanism of glutamate receptor desensitization p245

Yu Sun, Rich Olson, Michelle Horning, Neali Armstrong, Mark Mayer and Eric Gouaux

doi:10.1038/417245a

Abstract | Full Text | PDF (1,132K) | Supplementary information

See also: News and Views by Rosenmund & Mansour

Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis p254

M. B. Pepys, J. Herbert, W. L. Hutchinson, G. A. Tennent, H. J. Lachmann, J. R. Gallimore, L. B. Lovat, T. Bartfai, A. Alanine, C. Hertel, T. Hoffmann, R. Jakob-Roetne, R. D. Norcross, J. A. Kemp, K. Yamamura, M. Suzuki, G. W. Taylor, S. Murray, D. Thompson, A. Purvis, S. Kolstoe, S. P. Wood and P. N. Hawkins

doi:10.1038/417254a

Abstract | Full Text | PDF (373K)

See also: News and Views by Iversen

Letters to Nature

A reconstruction of the initial conditions of the Universe by optimal mass transportation p260

Uriel Frisch, Sabino Matarrese, Roya Mohayaee and Andrei Sobolevski

doi:10.1038/417260a

First paragraph | Full Text | PDF (334K)

Spectral evidence for weathered basalt as an alternative to andesite in the northern lowlands of Mars p263

Michael B. Wyatt and Harry Y. McSween, Jr

doi:10.1038/417263a

First paragraph | Full Text | PDF (327K) | Supplementary information

See also: News and Views by Mustard

Formation of tough interlocking microstructures in silicon nitride ceramics by dynamic ripening p266

Zhijian Shen, Zhe Zhao, Hong Peng and Mats Nygren

doi:10.1038/417266a

First paragraph | Full Text | PDF (376K) | Supplementary information

See also: News and Views by Thompson

Discrete stages in the solvation and ionization of hydrogen chloride adsorbed on ice particles p269

J. P. Devlin, N. Uras, J. Sadlej and V. Buch

doi:10.1038/417269a

First paragraph | Full Text | PDF (264K)

See also: News and Views by Leutwyler

A palaeontological solution to the arthropod head problem p271

Graham E. Budd

doi:10.1038/417271a

First paragraph | Full Text | PDF (295K) | Supplementary information

Climatic influence on a marine fish assemblage p275

Martin J. Attrill and Michael Power

doi:10.1038/417275a

First paragraph | Full Text | PDF (169K) | Supplementary information

Nonlinear grassland responses to past and future atmospheric CO₂ p279

Richard A. Gill, H. Wayne Polley, Hyrum B. Johnson, Laurel J. Anderson, Hafiz Maherali and Robert B. Jackson

doi:10.1038/417279a

First paragraph | Full Text | PDF (273K)

Dopamine-mediated modulation of odour-evoked amygdala potentials during pavlovian conditioning p282

J. Amiel Rosenkranz and Anthony A. Grace

doi:10.1038/417282a

First paragraph | Full Text | PDF (718K)

Stress response genes protect against lethal effects of sleep deprivation in Drosophila p287

Paul J. Shaw, Giulio Tononi, Ralph J. Greenspan and Donald F. Robinson

doi:10.1038/417287a

First paragraph | Full Text | PDF (352K) | Supplementary information

A common mechanism of action for three mood-stabilizing drugs p292

Robin S. B. Williams, Lili Cheng, Anne W. Mudge and Adrian J. Harwood

doi:10.1038/417292a

First paragraph | Full Text | PDF (332K)

The Wnt/calcium pathway activates NF-AT and promotes ventral cell fate in Xenopus embryos p295

Takeo Saneyoshi, Shoen Kume, Yoshiharu Amasaki and Katsuhiko Mikoshiba

doi:10.1038/417295a

First paragraph | Full Text | PDF (388K) | Supplementary information

See also: News and Views by Moon & Shah

Hedgehog regulates cell growth and proliferation by inducing Cyclin D and Cyclin E p299

Molly Duman-Scheel, Li Weng, Shijie Xin and Wei Du

doi:10.1038/417299a

First paragraph | Full Text | PDF (582K) | Supplementary information

TREX is a conserved complex coupling transcription with messenger RNA export p304

Katja Sträer, Seiji Masuda, Paul Mason, Jens Pfannstiel, Marisa Oppizzi, Susana Rodriguez-Navarro, Ana G. Rondón, Andres Aguilera, Kevin Struhl, Robin Reed and Ed Hurt

doi:10.1038/nature746

First paragraph | Full Text | PDF (352K) | Supplementary information

The dynamics of actin-based motility depend on surface parameters p308

Anne Bernheim-Groswasser, Sebastian Wiesner, Roy M. Golsteyn, Marie-France Carlier and Cécile Sykes

doi:10.1038/417308a

First paragraph | Full Text | PDF (222K) | Supplementary information

Rotavirus protein involved in genome replication and packaging exhibits a HIT-like fold p311

Hariharan Jayaram, Zenobia Taraporewala, John T. Patton and B. V. Venkataram Prasad

doi:10.1038/417311a

First paragraph | Full Text | PDF (403K) | Supplementary information

New on the Market

Microbiology media and methods p316

Detection, growth and sterilization.

doi:10.1038/417316a

Full Text | PDF (65K)

insight

Neurobiological systems p317

Hemai Parthasarathy

doi:10.1038/417317a

Full Text | PDF (129K)

Non-mammalian models for studying neural development and function p318

Eve Marder

doi:10.1038/417318a

Abstract | Full Text | PDF (322K)

Instructed learning in the auditory localization pathway of the barn owl p322

Eric I. Knudsen

doi:10.1038/417322a

Abstract | Full Text | PDF (982K)

Circadian rhythms from flies to human p329

Satchidananda Panda, John B. Hogenesch and Steve A. Kay

doi:10.1038/417329a

Abstract | Full Text | PDF (294K)

On the scents of smell in the salamander p336

John S. Kauer

doi:10.1038/417336a

Abstract | Full Text | PDF (1,725K)

A small-systems approach to motor pattern generation p343

Michael P. Nusbaum and Mark P. Beenhakker

doi:10.1038/417343a

Abstract | Full Text | PDF (1,645K)

What songbirds teach us about learning p351

Michael S. Brainard and Allison J. Doupe

doi:10.1038/417351a

Abstract | Full Text | PDF (858K)

Robots in invertebrate neuroscience p359

Barbara Webb

doi:10.1038/417359a

Abstract | Full Text | PDF (527K)

All Creatures Great and Small: National Institutes of Health p364

doi:10.1038/417364a

Full Text | PDF (96K)