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Nature 416, 691-694 (18 April 2002) | doi:10.1038/416691a
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DNA repair: Breaking the seal
Sebastian D. Fugmann
Abstract
The diversity of the receptors on our immune cells that recognize 'foreign' material is ensured by combining a set of gene segments to form the final receptor genes. A crucial player in that process has now been found.
One hallmark of our immune system is its ability to recognize and react efficiently to a nearly infinite variety of infectious microorganisms. Such remarkable versatility stems from a cut-and-paste process that rearranges the genome of immune cells as they develop.
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