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Nature 415, 967-969 (28 February 2002) | doi:10.1038/415967a
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Nuclear transplantation: A monoclonal mouse?
Janet Rossant
Abstract
One potential use of nuclear-transplantation — cloning — technology is to generate genetically matched tissues for treating adult patients. But there's a debate about whether mature adult cells are a good source of nuclei.
Behind all the fuss about the cloning of animals and prospects for cloning humans, some interesting scientific issues remain. For instance, can the nucleus of even the most specialized adult cell be completely 'reprogrammed', so that it can direct the development of a whole new embryo?
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