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Nature 415, 488-489 (31 January 2002) | doi:10.1038/415488b
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Bacterial behaviour: Function by serendipity
Dagmar Ringe1
Abstract
Crystallography has provided an unusual route to the characterization of a bacterial signalling agent: the molecule concerned has been accidentally caught in the clutches of its receptor.
In most of biology, research projects usually follow a hypothesis-driven path that starts with the identification of some activity or other and leads to knowledge of the detailed functions of the molecules responsible. Ultimately, complete characterization of function requires information at many levels of organization, and experiments of many kinds.
- Dagmar Ringe is at the Rosenstiel Basic Medical Sciences Research Center, Brandeis University, 415 South Street, Waltham, Massachusetts 02454-, USA.
Correspondence to: Dagmar Ringe1 e-mail: Email: ringe@binah.cc.brandeis.edu
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