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Nature 415, 26-27 (3 January 2002) | doi:10.1038/415026a
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Ageing: The price of tumour suppression?
Gerardo Ferbeyre1 & Scott W. Lowe2
Abstract
The p53 protein works to suppress cancer, so one might think that bumping up the levels of this protein would be a good idea. But this isn't so — mice with too much p53 age prematurely.
The p53 gene is often touted as 'the most frequently mutated gene in human cancer'. As a result, a great deal is known about it.
- Gerardo Ferbeyre is in the Department of Biochemistry, Université de Montréal, Montréal, Quebec, Canada, H3C 3J7.
e-mail: Email: g.ferbeyre@umontreal.ca - Scott W. Lowe is at the Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
e-mail: Email: lowe@cshl.edu
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