Access

News and Views

Nature 415, 26-27 (3 January 2002) | doi:10.1038/415026a

Open Innovation Challenges

naturejobs

Ageing: The price of tumour suppression?

Gerardo Ferbeyre1 & Scott W. Lowe2

Top

The p53 protein works to suppress cancer, so one might think that bumping up the levels of this protein would be a good idea. But this isn't so — mice with too much p53 age prematurely.

The p53 gene is often touted as 'the most frequently mutated gene in human cancer'. As a result, a great deal is known about it.

  1. Gerardo Ferbeyre is in the Department of Biochemistry, Université de Montréal, Montréal, Quebec, Canada, H3C 3J7.
    e-mail: Email: g.ferbeyre@umontreal.ca
  2. Scott W. Lowe is at the Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA.
    e-mail: Email: lowe@cshl.edu