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Brief Communications
Nature 414, 863-864 (20 December 2001) | doi:10.1038/414863a
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Health: Endothelin-1 synthesis reduced by red wine
Roger Corder1, Julie A. Douthwaite1, Delphine M. Lees1, Noorafza Q. Khan1, Ana Carolina Viseu dos Santos1, Elizabeth G. Wood1 & Martin J. Carrier1
Abstract
Red wines confer extra benefit when it comes to preventing coronary heart disease.
Abstract
Statistical evidence of reduced coronary heart disease in areas of high wine consumption has led to the widespread belief that wine affords a protective effect1, 2. Although moderate drinking of any alcohol helps to reduce the incidence of coronary heart disease3, 4, there is no clear evidence that red wine confers an additional benefit5. Here we show that red wines strongly inhibit the synthesis of endothelin-1, a vasoactive peptide that is crucial in the development of coronary atherosclerosis6. Our findings indicate that components specific to red wine may help to prevent coronary heart disease.
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