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Nature 414, 105-111 (1 November 2001) | doi:10.1038/35102167
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Gastroenterologist
- Gastrointestinal Diseases Inc.
- Georgia, USA
Postdoctoral Position
- Fox Chase Cancer Center
- Philadelphia, Pennsylvania, United States, 19111
review article Stem cells, cancer, and cancer stem cells
Tannishtha Reya1,4,5, Sean J. Morrison2,5, Michael F. Clarke3 & Irving L. Weissman1
Abstract
Stem cell biology has come of age. Unequivocal proof that stem cells exist in the haematopoietic system has given way to the prospective isolation of several tissue-specific stem and progenitor cells, the initial delineation of their properties and expressed genetic programmes, and the beginnings of their utility in regenerative medicine. Perhaps the most important and useful property of stem cells is that of self-renewal. Through this property, striking parallels can be found between stem cells and cancer cells: tumours may often originate from the transformation of normal stem cells, similar signalling pathways may regulate self-renewal in stem cells and cancer cells, and cancer cells may include 'cancer stem cells' — rare cells with indefinite potential for self-renewal that drive tumorigenesis.
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