Many organisms use natural peptides to ward off microbes, but it's proved hard to make similar molecules for medical use. A ring-shaped peptide that might puncture microbial membranes could be the way forward.
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Ganz, T. Rings of destruction. Nature 412, 392–393 (2001). https://doi.org/10.1038/35086680
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DOI: https://doi.org/10.1038/35086680
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