Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Biological catalysis

The hairpin's turn

A crystal structure of the hairpin ribozyme provides an atomic framework for understanding RNA catalysis, including features that may be common to both RNA and protein enzymes.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: RNA and protein enzymes.

References

  1. Rupert, P. B. & Ferré-D'Amaré, A. R. Nature 410, 780–786 (2001).

    Article  ADS  CAS  Google Scholar 

  2. Steitz, T. A. & Steitz, J. A. Proc. Natl Acad. Sci. USA 90, 6498–6502 (1993).

    Article  ADS  CAS  Google Scholar 

  3. Nesbitt, S., Hegg, L. A. & Fedor, M. J. Chem. Biol. 4, 619–630 (1997).

    Article  CAS  Google Scholar 

  4. Murray, J. B., Seyhan, A. A., Walter, N. G., Burke, J. M. & Scott, W. G. Chem. Biol. 5, 587–595 (1998).

    Article  CAS  Google Scholar 

  5. Cai, Z. & Tinoco, I. Biochemistry 35, 6026–6036 (1996).

    Article  CAS  Google Scholar 

  6. Butcher, S. E., Allain, F. H. & Feigon, J. Nature Struct. Biol. 6, 212–216 (1999).

    Article  CAS  Google Scholar 

  7. Hampel, K. J. & Burke, J. M. Biochemistry (in the press).

  8. Richards, F. M. et al. Cold Spring Harb. Symp. Quant. Biol. 36, 35–43 (1971).

    Article  CAS  Google Scholar 

  9. Deavin, A., Mathias, A. P. & Rabin, B. R. Nature 211, 252–255 (1966).

    Article  ADS  CAS  Google Scholar 

  10. Ferré-D'Amaré, A. R., Zhou, K. & Doudna, J. A. Nature 395, 567–574 (1998).

    Article  ADS  Google Scholar 

  11. Nakano, S., Chadalavada, D. M. & Bevilacqua, P. C. Science 287, 1493–1497 (2000).

    Article  ADS  CAS  Google Scholar 

  12. Muth, G. W., Ortoleva-Donnelly, L. & Strobel, S. A. Science 289, 947–950 (2000).

    Article  ADS  CAS  Google Scholar 

  13. Nissen, P., Hansen, J., Ban, N., Moore, P. & Steitz, T. Science 289, 920–930 (2000).

    Article  ADS  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Scott A. Strobel.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Strobel, S., Ryder, S. The hairpin's turn. Nature 410, 761–762 (2001). https://doi.org/10.1038/35071209

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/35071209

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing