Injury to one part of the body often results in hypersensitivity to pain somewhere else. Unusually, this process seems to be coordinated by the brain in a way that does not involve the transmission of nerve impulses.
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References
Dantzer, R. et al. Ann. NY Acad. Sci. 856, 132–138 (1988).
Samad, T. A. et al. Nature 410, 471–475 (2001).
Ek, M. et al. Nature 410, 430–431 (2001).
Vane, J. R., Bakhle, Y. S. & Botting, R. M. Annu. Rev. Pharmacol.Toxicol. 38, 97–120 (1998).
Griffiths, R. in Inflammation: Basic Principles and Clinical Correlates (eds Gallin, J. & Snyderman, R.) 349–360 (Lippincott Williams and Wilkins, Philadelphia, 1999).
Stock, J. L. et al. J. Clin. Invest. 107, 325–331 (2001).
Ushikubi, F. et al. Nature 395, 281–284 (1998).
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Bartfai, T. Telling the brain about pain. Nature 410, 425–427 (2001). https://doi.org/10.1038/35068663
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DOI: https://doi.org/10.1038/35068663
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