Figures and Tables
From the following article:
Initial sequencing and analysis of the human genome
and International Human Genome Sequencing Consortium
Nature 409, 860-921(15 February 2001)
Figure 2
Idealized representation of the hierarchical shotgun sequencing strategy.
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Figure 3
The automated production line for sample preparation at the Whitehead Institute, Center for Genome Research.
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Figure 4
Total amount of human sequence in the High Throughput Genome Sequence (HTGS) division of GenBank.
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Figure 5
Positions of markers on previous maps of the genome (the Genethon101 genetic map and Marshfield genetic map (http://research.marshfieldclinic.org/genetics/genotyping_service/mgsver2.htm ), the GeneMap99 radiation hybrid map100, and the Whitehead YAC and radiation hybrid map29) plotted against their derived position on the draft sequence for chromosome 2.
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Figure 6
The key steps (a–d) in assembling individual sequenced clones into the draft genome sequence.
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Figure 8
Cumulative distributions of several measures of clone level contiguity and sequence contiguity.
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Figure 12
Histogram of GC content of 20-kb windows in the draft genome sequence.
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Figure 14
Number of CpG islands per Mb for each chromosome, plotted against the number of genes per Mb (the number of genes was taken from GeneMap98 (ref.100)).
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Figure 15
Distance in cM along the genetic map of chromosome 12 plotted against position in Mb in the draft genome sequence.
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Figure 16
Rate of recombination averaged across the euchromatic portion of each chromosome arm plotted against the length of the chromosome arm in Mb.
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Figure 17
Almost all transposable elements in mammals fall into one of four classes.
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Figure 18
Age distribution of interspersed repeats in the human and mouse genomes.
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Figure 19
Median ages and per cent of the genome covered by subfamilies of DNA transposons.
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Figure 20
Comparison of the age of interspersed repeats in eukaryotic genomes.
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Figure 22
Density of the major repeat classes as a function of local GC content, in windows of 50 kb.
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Figure 23
Alu elements target AT-rich DNA, but accumulate in GC-rich DNA.
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Figure 24
DNA transposon copies in AT-rich DNA tend to be younger than those in more GC-rich DNA.
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Figure 25
Distribution of various LINE cohorts as a function of local GC content.
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Figure 26
Comparison of the Alu density of each chromosome as a function of local GC content.
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Figure 27
Substitution patterns in interspersed repeats differ as a function of GC content.
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Figure 28
Interspersed repeats tend to diminish the differences between GC bins, despite the fact that GC-rich transposable elements (specifically Alu) accumulate in GC-rich DNA, and AT-rich elements (LINE1) in AT-rich DNA.
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Figure 29
Higher substitution rate on chromosome Y than on chromosome X.
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Figure 35
Size distributions of exons, introns and short introns, in sequenced genomes.
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Figure 38
Distribution of the homologues of the predicted human proteins.
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Figure 39
Simplified cladogram (relationship tree) of the 'many-to-many' relationships of classical nuclear receptors.
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Figure 40
Number of distinct domain architectures in the four eukaryotic genomes, predicted using SMART339.
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Figure 41
Number of different Pfam domain types that co-occur in the same protein, for each of the 10 most common domain families in each of the five eukaryotic proteomes.
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Figure 44
Relative expansions of protein families between human and fly.
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Figure 45
Lineage-specific expansions of domains and architectures of transcription factors.
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Figure 47
Distribution of number of genes per conserved segment between human and mouse genomes.
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Figure 48
Distribution of lengths (in 5-Mb bins) of conserved segments between human and mouse genomes, omitting singletons.
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Figure 49
Number of human paralogues of genes having single orthologues in worm and fly.
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Table 2
Total genome sequence from the collection of sequenced clones, by sequence status
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Number of copies and fraction of genome for classes of interspersed repeat
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Fraction of finished sequence in inter- and intrachromosomal duplications
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Fraction of the draft genome sequence in inter- and intrachromosomal duplications
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Cross-species comparison for large, highly homologous segmental duplications
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Properties of genome and proteome in essentially completed eukaryotic proteomes
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The most populous InterPro families in the human proteome and other species
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New paralogues of common drug targets identified by searching the draft human genome sequence
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