FIGURE 1. Lmx1b encodes a transcription factor that helps to control the trajectory of motor axons during mammalian limb development.

a, The results of a search of the six-frame translation of the draft genome sequence on the NCBI site using mouse Lmx1b protein NP_034855.1 as a query and using TBLASTN with standard search parameters. The best match was to a region of chromosome 9 that contains the human LMX1B gene. b, The mouse Lmx1b and the human LMX1B genes lie within a conserved syntenic block of genes, in mouse on chromosome 2 and in human on chromosome 9. This conservation of gene order supports the theory that Lmx1b and LMX1B are orthologous.