Abstract

The cloning and characterization of 'clock gene' families has advanced our understanding of the molecular control of the mammalian circadian clock. We have analysed the human genome for additional relatives, and identified new candidate genes that may expand our knowledge of the molecular workings of the circadian clock. This knowledge could lead to the development of therapies for treating jet lag and sleep disorders, and add to our understanding of the genetic contribution of clock gene alterations to sleep and neuropsychiatric disorders. The human genome will also aid in the identification of output genes that ultimately control circadian behaviours.

1. Department of Genetics, University of Leicester, Leicester LE1 7RH, UK
2. Laboratory of Developmental Chronobiology, MassGeneral Hospital for Children, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA

Correspondence to: Steven M. Reppert² Correspondence and requests for materials should be addressed to S.M.R. (e-mail: Email: reppert@helix.mgh.harvard.edu).