Table of contents
Volume 405 Number 6789 pp869-980
Opinion
A significant time for Europe p869
After languishing in recent years, the vision of a research community operating effectively at a European level is being actively pursued. Larger member states should give it their support.
doi:10.1038/35016203
Welcome Nature Immunology p869
Next week sees the birth of a new Nature journal.
doi:10.1038/35016205
News
German fraud inquiry casts a wider net of suspicion... p871
Alison Abbott
doi:10.1038/35016207
...as disillusionment reigns in task force p871
Alison Abbott
doi:10.1038/35016211
Oxford epidemiologist wins apology for promotion slur p872
Natasha Loder
doi:10.1038/35016213
Hawaii reaches for the stars with astronomy master plan p872
Rex Dalton and Alison Abbott
doi:10.1038/35016216
Europe edges closer to an integrated science policy p873
Quirin Schiermeier
doi:10.1038/35016219
UK panel calls for more cuts to carbon dioxide emission p873
Natasha Loder
doi:10.1038/35016222
Brookhaven collider opens its quest for Big Bang conditions p874
Steve Nadis
doi:10.1038/35016225
Shares rebound at scent of draft sequence p875
Paul Smaglik
doi:10.1038/35016228
GM food 'dumped on India as aid' p875
K. S. Jayaraman
doi:10.1038/35016231
News Feature
A question of trust p878
It is the world's biggest medical research charity and it exerts a huge influence over UK science policy. But is the Wellcome Trust becoming a victim of its own success, asks Natasha Loder.
Natasha Loder
doi:10.1038/35016236
The rise and rise of Wellcome p879
doi:10.1038/35016244
Correspondence
Leatherback's survival will depend on an international effort p881
Larry Crowder
doi:10.1038/35016247
Biotech pioneers have duties as well as rights p881
Bao-Hong Zhang
doi:10.1038/35016249
Don't ignore good work that you have to look for p881
Jerry Lanchbury
doi:10.1038/35016251
Database could give children safer medicines p882
Piero Impicciatore, Chiara Pandolfini and Maurizio Bonati
doi:10.1038/35016256
Japan may seek embryo cells from overseas p882
Tohru Nakanishi
doi:10.1038/35016258
Book Reviews
The great Dane of Uraniborg p883
The story of how astute manipulation of the system facilitated world renown.
Kenneth J. Howell reviews On Tycho's Island: Tycho Brahe and His Assistants, 1570–1601 by John Robert Christianson
doi:10.1038/35016133
An alchemist of our times p884
Lars-Håkan Svensson reviews Memory Effects by Roald Hoffmann
doi:10.1038/35016137
New in paperback p884
doi:10.1038/35016139
Sex, leaves and rock and roll p885
Sandra Knapp reviews The Ingenious Mr Fairchild: The Forgotten Father of the Flower Garden by Michael Leapman
doi:10.1038/35016141
One man's weed ... p885
doi:10.1038/35016143
Science in culture p886
Martin Kemp reviews
doi:10.1038/35016145
Millennium Essay
The well-spring p887
About 3,000 years ago, the Greeks invented science.
Lewis Wolpert
doi:10.1038/35016166
Futures
In the days of the comet p889
Dispatch 135 from the Oort Cloud Survey.
John M. Ford
doi:10.1038/35016169
News and Views
Computational Neuroscience: Neural circuits in silicon p891
Studies of neurally inspired silicon circuits are showing how networks of neurons can select and multiply input signals. They may also provide alternative ways to build computers modelled on biology.
Chris Diorio and Rajesh P. N. Rao
doi:10.1038/35016172
Neurobiology: Self-repair in the brain p892
Anders Björklund and Olle Lindvall
doi:10.1038/35016175
100 and 50 years ago p893
doi:10.1038/35016178
Ecology: Shrimp-eat-shrimp p895
John Whitfield
doi:10.1038/35016180
Chemistry: Chirality, magnetism and light p895
Laurence D. Barron
doi:10.1038/35016183
Genetics: Reverse gear for Drosophila p896
Barry J. Dickson
doi:10.1038/35016186
Semiconductor physics: Electrons in artificial atoms p899
Daniel Gammon
doi:10.1038/35016189
Malaria: A mosquito transformed p900
Craig J. Coates
doi:10.1038/35016192
Oceanography: Given a twirl p901
Heike Langenberg
doi:10.1038/35016195
Daedalus: Solid explosion p901
David Jones
doi:10.1038/35016198
Obituary: Kent R. Wilson (1937–2000) p902
Dudley Herschbach
doi:10.1038/35016200
Brief Communications
Whale songs lengthen in response to sonar p903
Male humpbacks modify their sexual displays when exposed to man-made noise.
Patrick J. O. Miller, Nicoletta Biassoni, Amy Samuels and Peter L. Tyack
doi:10.1038/35016148
First paragraph | Full Text | PDF (93K)
Nutrition: Antioxidant activity of fresh apples p903
Marian V. Eberhardt, Chang Yong Lee and Rui Hai Liu
doi:10.1038/35016151
First paragraph | Full Text | PDF (93K)
Botany: Constraints to growth of boreal forests p904
Paul Jarvis and Sune Linder
doi:10.1038/35016154
First paragraph | Full Text | PDF (91K)
reply: Constraints to growth of boreal forests p905
Eugene A. Vaganov and Malcolm K. Hughes
doi:10.1038/35016157
First paragraph | Full Text | PDF (71K)
Review
The genetic legacy of the Quaternary ice ages p907
Godfrey Hewitt
doi:10.1038/35016000
Abstract | Full Text | PDF (368K)
Article
Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export p914
Vassilis Koronakis, Andrew Sharff, Eva Koronakis, Ben Luisi and Colin Hughes
doi:10.1038/35016007
Abstract | Full Text | PDF (497K)
Letters to Nature
Optical detection of meteoroidal impacts on the Moon p921
J. L. Ortiz, P. V. Sada, L. R. Bellot Rubio, F. J. Aceituno, J. Aceituno, P. J. Gutiérrez and U. Thiele
doi:10.1038/35016015
First paragraph | Full Text | PDF (247K)
Hidden symmetries in the energy levels of excitonic 'artificial atoms' p923
M. Bayer, O. Stern, P. Hawrylak, S. Fafard and A. Forchel
doi:10.1038/35016020
First paragraph | Full Text | PDF (288K)
See also: News and Views by Gammon
Optical emission from a charge-tunable quantum ring p926
R. J. Warburton, C. Schäflein, D. Haft, F. Bickel, A. Lorke, K. Karrai, J. M. Garcia, W. Schoenfeld and P. M. Petroff
doi:10.1038/35016030
First paragraph | Full Text | PDF (291K)
See also: News and Views by Gammon
Gigantic optical nonlinearity in one-dimensional Mott–Hubbard insulators p929
H. Kishida, H. Matsuzaki, H. Okamoto, T. Manabe, M. Yamashita, Y. Taguchi and Y. Tokura
doi:10.1038/35016036
First paragraph | Full Text | PDF (234K)
Enantioselective magnetochiral photochemistry p932
G. L. J. A. Rikken and E. Raupach
doi:10.1038/35016043
First paragraph | Full Text | PDF (189K)
See also: News and Views by Barron
Reduced North Atlantic Deep Water flux to the glacial Southern Ocean inferred from neodymium isotope ratios p935
Randye L. Rutberg, Sidney R. Hemming and Steven L. Goldstein
doi:10.1038/35016049
First paragraph | Full Text | PDF (163K)
Mapping the Hawaiian plume conduit with converted seismic waves p938
X. Li, R. Kind, K. Priestley, S. V. Sobolev, F. Tilmann, X. Yuan and M. Weber
doi:10.1038/35016054
First paragraph | Full Text | PDF (451K) | Supplementary information
A pug-nosed crocodyliform from the Late Cretaceous of Madagascar p941
Gregory A. Buckley, Christopher A. Brochu, David W. Krause and Diego Pol
doi:10.1038/35016061
First paragraph | Full Text | PDF (274K) | Supplementary information
Diversity and endemism of the benthic seamount fauna in the southwest Pacific p944
Bertrand Richer de Forges, J. Anthony Koslow and G. C. B. Poore
doi:10.1038/35016066
First paragraph | Full Text | PDF (177K)
Digital selection and analogue amplification coexist in a cortex-inspired silicon circuit p947
Richard H. R. Hahnloser, Rahul Sarpeshkar, Misha A. Mahowald, Rodney J. Douglas and H. Sebastian Seung
doi:10.1038/35016072
First paragraph | Full Text | PDF (172K) | Supplementary information
See also: News and Views by Diorio & Rao
Induction of neurogenesis in the neocortex of adult mice p951
Sanjay S. Magavi, Blair R. Leavitt and Jeffrey D. Macklis
doi:10.1038/35016083
First paragraph | Full Text | PDF (346K)
See also: News and Views by Björklund & Lindvall
Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity p955
Hey-Kyoung Lee, Michaela Barbarosie, Kimihiko Kameyama, Mark F. Bear and Richard L. Huganir
doi:10.1038/35016089
First paragraph | Full Text | PDF (363K)
Stable germline transformation of the malaria mosquito Anopheles stephensi p959
Flaminia Catteruccia, Tony Nolan, Thanasis G. Loukeris, Claudia Blass, Charalambos Savakis, Fotis C. Kafatos and Andrea Crisanti
doi:10.1038/35016096
First paragraph | Full Text | PDF (342K)
See also: News and Views by Coates
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis p962
C. Kendall Stover, Paul Warrener, Donald R. VanDevanter, David R. Sherman, Taraq M. Arain, Michael H. Langhorne, Scott W. Anderson, J. Andrew Towell, Ying Yuan, David N. McMurray, Barry N. Kreiswirth, Clifton E. Barry and William R. Baker
doi:10.1038/35016103
First paragraph | Full Text | PDF (257K)
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1 p966
Stacey S. Huppert, Anh Le, Eric H. Schroeter, Jeffrey S. Mumm, Meera T. Saxena, Laurie A. Milner and Raphael Kopan
doi:10.1038/35016111
First paragraph | Full Text | PDF (398K)
An extracellular activator of the Drosophila JAK/STAT pathway is a sex-determination signal element p970
Louise Sefton, John R. Timmer, Yan Zhang, Florence Béranger and Thomas W. Cline
doi:10.1038/35016119
First paragraph | Full Text | PDF (239K)
Compromised HOXA5 function can limit p53 expression in human breast tumours p974
Venu Raman, Shelby A. Martensen, David Reisman, Ella Evron, Ward F. Odenwald, Elizabeth Jaffee, Jeffrey Marks and Saraswati Sukumar
doi:10.1038/35016125
First paragraph | Full Text | PDF (384K) | Supplementary information
New on the Market
Instrumental in analysis p979
Analytical instruments, from electric nose to GasHound.
doi:10.1038/35016159
