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Nature 404, 538-540 (6 April 2000) | doi:10.1038/35007253

Open Innovation Challenges

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Whatever happened to leptin?

Marina Chicurel1

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Just five years ago, it seemed that a single protein might reverse the rising tide of obesity. What worked for mice has not yet translated to people. But watch this space, says Marina Chicurel.

By any reckoning, US$20 million is a lot to spend on a protein. But in May 1995, Amgen of Thousand Oaks, California, paid just that for the commercial rights to leptin, a hormone that made fat mice slim.