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Nature 393, 739-740 (25 June 1998) | doi:10.1038/31597

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Signal transduction:  Actin, cofilin and cognition

Jody Rosenblatt1 & Timothy J. Mitchison2

Patients with Williams syndrome, a multi-gene deletion syndrome, suffer from mild mental retardation and vascular disease. They also have defects in visuo-spatial cognition — a failure to integrate parts into a whole — that are linked to deletion of the gene that codes for LIM-kinase 1 (LIMK-1)1.

  1. Jody Rosenblatt is in the Department of Biochemistry, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, California 94143, USA.
    e-mail: Email: jody@cgl.ucsf.edu
  2. Timothy J. Mitchison is in the Department of Cell Biology, Harvard Medical School, Room C517, 240 Longwood Avenue, Boston, MassachusettsM 02115, USA.
    e-mail: Email: Timothy_Mitchison@hms.harvard.edu