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An E2F-like repressor of transcription

Nature volume 390, pages 567–568 (1997)Cite this article

Abstract

The activity of a variety of genes whose products are involved in DNA replication and cell-cycle progression are regulated by E2F transcription factors, which bind to E2F sites on DNA in cooperation with members of the DP family of transcription factors1. E2F sites can act as both positive and negative control elements2. Transcriptional activation from E2F sites is mediated by ‘free’ E2F, whereas repression conventionally requires the formation of a complex with a pocket protein (retinoblastoma protein (RB), p107 or p130)3. Here we describe an E2F-like protein, termed EMA (for E2F-binding site modulating activity), which can act as a repressor of transcription without a pocket protein.

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Figure 1: EMA is a transcriptional repressor.

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Author information

Authors and Affiliations

  1. Laboratory for Molecular Biology of Pediatric Disease, Charit, Humboldt University, Zeigelstrasse 5-9, D-10098, Berlin, Germany

    M. Morkel & J. Wenkel

  2. Wellcome/CRC Institute and Department of Pathology, University of Cambridge, Tennis Court Road, CB2 1QR, Cambridge, UK

    A. J. Bannister & T. Kouzarides

  3. Department of Paediatrics, Charit-Virchow Medical Center, Humboldt University, Augustenburger Platz 1, D-13353, Berlin, Germany

    Christian Hagemeier

Authors
  1. M. Morkel
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  2. J. Wenkel
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  3. A. J. Bannister
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  4. T. Kouzarides
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  5. Christian Hagemeier
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Morkel, M., Wenkel, J., Bannister, A. et al. An E2F-like repressor of transcription. Nature 390, 567–568 (1997). https://doi.org/10.1038/37507

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