Nature 381, 69 - 71 (02 May 1996); doi:10.1038/381069a0

Central reorganization of sensory pathways following peripheral nerve regeneration in fetal monkeys

Sherre L. Florence^*, Neeraj Jain^*, Marcie W. Pospichal, Pam D. Beck^*, D. Lewis Sly^† & Jon H. Kaas^*

Departments of ^* Psychology and ^† Pathology, Vanderbilt University, Nashville, Tennessee 37240, USA

TRANSECTION of a sensory nerve in adults results in profound abnormalities in sensory perception, even if the severed nerve is surgically repaired to facilitate accurate nerve regeneration. In marked contrast, fewer perceptual errors follow nerve transection and surgical repair in children^1–3. The basis for this superior recovery in children was unknown. Here we show that there is little or no topographic order in the median nerve to the hand after median nerve section and surgical repair in immature macaque monkeys. Remarkably, however, in the same animals the representation of the reinnervated hand in primary somato-sensory cortx (area 3b) is quite orderly. This indicates that there are mechanisms in the developing brain that can create cortical topography, despite disordered sensory inputs. Presumably the superior recovery of perceptual abilities after peripheral nerve transection in children depends on this restoration of somatotopy in the central sensory maps.

References

1.	Buchthal, F. & Kuhl, V. J. NeuroL. Neurosurg. Psych. 42, 436−451 (1979). | ChemPort |
2.	Dellon, A. L. Evaluation and Sensibility and Re-education of Sensation in the Hand (Williams and Wilkins, Baltimore, 1981).
3.	Hallin, R. G., Wiesenfeld, Z. & Lindblom, U. Exp. Neurol. 73, 90−106 (1981). | Article | PubMed | ChemPort |
4.	Florence, S. L., Garraghty, P. E., Wall, J. T. & Kaas, J. H. Cerebral Cortex 4, 391−407 (1994). | PubMed | ChemPort |
5.	Fitzgerald, M. J. comp. Neurol. 240, 407−413 (1985). | Article | PubMed | ChemPort |
6.	Jain, N., Florence, S. L. & Kaas, J. H. Devl. Brain Res. 90, 24−34 (1995). | ChemPort |
7.	Pons, T. P., Wall, J. T., Garraghty, P. E., Cusick, C. G. & Kaas, J. H. Somatosens. Res. 4, 309−331 (1987). | PubMed | ChemPort |
8.	Darian-Smith, C., Darian-Smith, I. & Cheema, S. S. J. comp. Neurol. 299, 47−63 (1990). | Article | PubMed | ChemPort |
9.	Hebb, D. O. Organization of Behavior (Wiley, New York, 1949).
10.	Stent, G. S. Proc. natn. Acad. Sci. U.S.A. 70, 997−1001 (1973). | ChemPort |
11.	Changeux, J. P. & Danchin, A. Nature 264, 705−712 (1976). | Article | PubMed | ISI | ChemPort |
12.	Hubel, D. H. & Wiesel, T. N. Proc. R. Soc. Lond. 198, 1−59 (1977). | ISI | ChemPort |
13.	Shatz, C. J. & Sretevan, D. W. A. Rev. Neurosci. 9, 171−207 (1986). | ChemPort |
14.	Cline, H. T. & Constantine-Paton, M. in Vision and Visual Dysfunction, 11. Development and Plasticity of the Visual System (ed. Cronly Dillon, J. R.) (CRC, Boca Raton, 1991).
15.	Kaas, J. H., Merzenich, M. M. & Killackey, H. P. A. Rev. Neurosci. 6, 325−356 (1983). | ChemPort |
16.	Woolsey, T. A. in Development of Sensory Systems in Mammals (ed. Coleman, J.) (Wiley, New York, 1990).
17.	O'Leary, D. D. M., Ruff, N. L. & Dyck, R. L. Curr. Opin. Neurobiol. 4, 535−544 (1994). | Article | PubMed | ChemPort |
18.	Killackey, H. P., Rhoades, R. W. & Bennett-Clarke, C. A. Trends Neurosci. 18, 402−407 (1995). | Article | PubMed | ISI | ChemPort |
19.	Bunnell, S. Surgery of the Hand (Lippincott, Philadelphia, 1956).