Abstract
TRANSFORMING growth factor-beta (TGF-β) inhibits cell proliferation by inducing a Gl-phase cell cycle arrest1. Normal progression through Gl is promoted by the activity of the cyclin-dependent protein kinases CDK4 and CDK6 (ref. 2), which are inhibited by the protein p16INK4. We have isolated a new member of the p16INK4 family, p15INK4B. p15 expression is induced ∼30-fold in human keratinocytes by treatment with TGF-β, suggesting that pi5 may act as an effector of TGF-β-mediated cell cycle arrest. The gene encoding p15 is located on chromosome 9 adjacent to the p16 gene at a frequent site of chromosomal abnormality in human tumours (9p21).
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Massague, J. A. Rev. Cell Biol. 6, 597–641 (1990).
Sherr, C. J. Cell 73, 1059–1065 (1993).
Bates, S. et al. Oncogene 9, 71–79 (1994).
Meyerson, M. & Harlow, E. Molec. cell. Biol. 14, 2077–2086 (1994).
Laiho, M., DeCaprio, J. A., Ludlow, J. W., Livingston, D. M. & Massague, J. Cell 62, 175–185 (1990).
Pietenpol, J. et al. Cell 61, 777–785 (1990).
Boukamp, P. et al. J. Cell Biol. 106, 761–771 (1988).
Geng, Y. & Weinberg, R. A. Proc. natn. Acad. Sci. U.S.A. 90, 10315–10319 (1993).
Serrano, M., Hannon, G. J. & Beach, D. Nature 366, 704–707 (1993).
Kamb, A. et al. Science 264, 436–440 (1994).
Ewen, M. E., Sluss, H. K., Whitehouse, L. L. & Livingston, D. M. Cell 74, 1009–1020 (1993).
Polyak, K. et al. Cell 78, 59–66 (1994).
Toyoshima, H. & Hunter, T. Cell 78, 67–74 (1994).
Polyak, K. et al. Genes Dev. 8, 9–22 (1994).
Bello, M. J., et al. Genes Chromosomes Cancer 9, 33–41 (1994).
Merlo, A., Gabrielson, E., Askin, F. & Sidransky, D. Cancer Res. 54, 640–642 (1994).
Cheng, J. Q., Jhanwar, S. C., Lu, Y. Y. & Testa, J. R. Cancer Res. 53, 4761–4763 (1993).
Petty, E. M. et al. Am. J. hum. Genet. 53, 96–104 (1993).
Fountain, J. E. et al. Proc. natn. Acad. Sci. U.S.A. 89, 10557–10561 (1992).
Cannon-Albright, L. A. et al. Science 258, 1148–1152 (1992).
Nobori, T. et al. Nature 368, 753–756 (1994).
Xiong, Y., Zhang, H. & Beach, D. Genes Dev. 7, 1572–1583 (1993).
Moses, H. L. et al. in Cancer Cells (eds Feramisco, J., Ozanne, B. & Stiles, C.) 3, 65–71 (1985).
Masui, T. et al. Proc. natn. Acad. Sci. U.S.A. 83, 2438–2442 (1986).
Manning, A. M., Williams, A. C., Gamie, S. M. & Paraskeva, C. Oncogene 6, 1471–1476 (1991).
Rodeck, U. et al. Cancer Res. 54, 575–581 (1994).
Hannon, G. J., Demetrick, D. & Beach, D. & Beach, D. Genes Dev. 7, 2378–2391 (1993).
Xiong, Y. et al. Nature 366, 701–704 (1993).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Hannon, G., Beach, D. pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest. Nature 371, 257–261 (1994). https://doi.org/10.1038/371257a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/371257a0
This article is cited by
-
Unraveling the prevalence of various signalling pathways in non-small-cell lung cancer: a review
Molecular and Cellular Biochemistry (2023)
-
Therapeutic potential of CDK4/6 inhibitors in renal cell carcinoma
Nature Reviews Urology (2022)
-
Genome-wide transcriptome profiling of human trabecular meshwork cells treated with TGF-β2
Scientific Reports (2022)
-
Genetic association between CDKN2B/CDKN2B-AS1 gene polymorphisms with primary glaucoma in a North Indian cohort: an original study and an updated meta-analysis
BMC Medical Genomics (2021)
-
The distinct effects of P18 overexpression on different stages of hematopoiesis involve TGF-β and NF-κB signaling
Scientific Reports (2021)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.