Abstract
A pool of endogenous peptides bound to the human class I MHC molecule, HLA-B27, has been isolated. Microsequence analysis of the pool and of 11 HPLC-purified peptides provides information on the binding specificity of the HLA-B27 molecule. The peptides all seem to be nonamers, seven of which match to protein sequences in a database search. These self peptides derive from abundant cytosolic or nuclear proteins, such as histone, ribosomal proteins, and members of the 90K heat-shock protein family.
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Jardetzky, T., Lane, W., Robinson, R. et al. Identification of self peptides bound to purified HLA-B27. Nature 353, 326–329 (1991). https://doi.org/10.1038/353326a0
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DOI: https://doi.org/10.1038/353326a0
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