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The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

Nature volume 348, pages 693–699 (1990)Cite this article

Abstract

The let-23 gene is required for induction of the Caenorhabditis elegans vulva. It is shown that let-23 encodes a putative tyrosine kinase of the epidermal growth factor receptor subfamily. Thus, let-23 might encode the receptor for the inductive signal required for vulval development. Because let-23 acts upstream of let-60 ras in the vulval determination pathway, the identification of the let-23 product provides support for a link in vivo between tyrosine kinase growth factor receptors and ras proteins in a pathway of cell-type determination.

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References

  1. Sulston, J. E. & Horvitz, H. R. Devl Biol. 56, 110–156 (1977).

    Article  CAS  Google Scholar 

  2. Sulston, J. E. & White, J. G. Devl Biol. 78, 577–597 (1980).

    Article  CAS  Google Scholar 

  3. Sternberg, P. W. Nature 335, 551–554 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  4. Sternberg, P. W. & Horvitz, H. R. Cell 58, 679–693 (1989).

    Article  CAS  PubMed  Google Scholar 

  5. Kimble, J. Devl Biol. 87, 286–300 (1981).

    Article  CAS  Google Scholar 

  6. Sternberg, P. W. & Horvitz, H. R. Cell 44, 761–772 (1986).

    Article  CAS  PubMed  Google Scholar 

  7. Thomas, J. H., Stern, M. J. & Horvitz, H. R. Cell 62, 1041–1052 (1990).

    Article  CAS  PubMed  Google Scholar 

  8. Horvitz, H. R. & Sulston, J. E. Genetics 96, 435–454 (1980).

    CAS  PubMed  PubMed Central  Google Scholar 

  9. Sulston, J. E. & Horvitz, H. R. Devl Biol. 82, 41–55 (1981).

    Article  CAS  Google Scholar 

  10. Ferguson, E. L. & Horvitz, H. R. Genetics 110, 17–72 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

  11. Ferguson, E. L., Sternberg, P. W. & Horvitz, H. R. Nature 326, 259–267 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  12. Kim, S. & Horvitz, H. R. Genes Dev. 4, 357–371 (1990).

    Article  CAS  PubMed  Google Scholar 

  13. Han, M., Aroian, R. & Sternberg, P. W. Genetics 126, 899–913 (1990).

    CAS  PubMed  PubMed Central  Google Scholar 

  14. Bietel, G. J., Clark, S. G. & Horvitz, H. R. Nature 348, 503–509 (1990).

    Article  ADS  Google Scholar 

  15. Han, M. & Sternberg, P. W. Cell 63, 921–931 (1990).

    Article  CAS  PubMed  Google Scholar 

  16. Ferguson, E. L. & Horvitz, H. R. Genetics 123, 109–121 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  17. Herman, R. K. & Hedgecock, E. M. Nature 348, 169–171 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  18. Herman, R. K. Genetics 88, 49–65 (1978).

    CAS  PubMed  PubMed Central  Google Scholar 

  19. Coulson, A. R., Sulston, J., Brenner, S. & Karn, J. Proc. natn. Acad. Sci. U.S.A. 83, 7821–7825 (1986).

    Article  ADS  CAS  Google Scholar 

  20. Coulson, A., Waterston, R., Kiff, J., Sulston, J. & Kohara, Y. Nature 335, 184–186 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  21. Neckameyer, W. S. & Wang, L. J. Virol. 53, 879–884 (1985).

    CAS  PubMed  PubMed Central  Google Scholar 

  22. Hanks, S. K., Quinn, A. M. & Hunter, T. Science 241, 42–52 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  23. Ullrich, A. et al. Nature 309, 418–425 (1984).

    Article  ADS  CAS  PubMed  Google Scholar 

  24. Livneh, E., Glazer, L., Segal, D., Schelssinger, J. & Shilo, B. Cell 40, 599–607 (1985).

    Article  CAS  PubMed  Google Scholar 

  25. Wittbrodt, J. et al. Nature 341, 415–421 (1989).

    Article  ADS  CAS  PubMed  Google Scholar 

  26. Watson, M. E. E. Nucleic Acids Res. 12, 5145–5164 (1984).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Kyte, J. & Doolittle, R. F. J. molec. Biol. 157, 105–132 (1982).

    Article  CAS  PubMed  Google Scholar 

  28. Kamps, M. P. & Sefton, B. M. Molec. cell. Biol. 6, 751–757 (1986).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Hunter, T. & Cooper, J. A. in The Enzymes Vol. 17 (eds Boyer, P. D. & Krebs, E. G.) 191–246 (Academic, Orlando, USA, 1986).

    Google Scholar 

  30. Carpenter, G. & Cohen, S. A. Rev. Biochem. 48, 193–216 (1979).

    Article  CAS  Google Scholar 

  31. Schlessinger, J. et al. CRC crit. Rev. Biochem. 14, 93–111 (1983).

    Article  CAS  PubMed  Google Scholar 

  32. Greenwald, I. S., Sternberg, P. W. & Horvitz, H. R. Cell 34, 435–444 (1983).

    Article  CAS  PubMed  Google Scholar 

  33. Yochem, J., Weston, K. & Greenwald, I. S. Nature 335, 547–550 (1988).

    Article  ADS  CAS  PubMed  Google Scholar 

  34. Seydoux, G. & Greenald, I. S. Cell 57, 1237–1245 (1989).

    Article  CAS  PubMed  Google Scholar 

  35. Mulcahy, L. S., Smith, M. R. & Stacey, D. W. Nature 313, 241–243 (1985).

    Article  ADS  CAS  PubMed  Google Scholar 

  36. Weissman, B. E. & Aronson, S. A. Cell 32, 599–606 (1983).

    Article  CAS  PubMed  Google Scholar 

  37. Parsons, J. T. Trends Genet. 6, 169–171 (1990).

    Article  CAS  PubMed  Google Scholar 

  38. Kazlauskas, A., Ellis, C., Pawson, T. & Cooper, J. A. Science 24, 1578–1581 (1990).

    Article  ADS  Google Scholar 

  39. Kaplan, D. R., Morrison, D. K., Wong, G., McCormick, F. & Williams, L. T. Cell 61, 125–133 (1990).

    Article  CAS  PubMed  Google Scholar 

  40. Ellis, C., Moran, M., McCormick, F. & Pawson, T. 1990. Nature, 343, 377–381 (1980).

    Article  ADS  CAS  PubMed  Google Scholar 

  41. Trahey, M. & McCormick, F. Science 238, 542–545 (1987).

    Article  ADS  CAS  PubMed  Google Scholar 

  42. Gibbs, J. B., Schaber, M. D., Allard, W. J., Sigal, I. S. & Scolnick E. M. Proc. natn. Acad. Sci. U.S.A. 85, 5026–5030 (1988).

    Article  ADS  CAS  Google Scholar 

  43. Zhang, K. et al., Nature 346, 754–756 (1990).

    Article  ADS  CAS  PubMed  Google Scholar 

  44. Ruvkun, G. et al. Genetics 121, 501–516 (1989).

    CAS  PubMed  PubMed Central  Google Scholar 

  45. Sulston, J. E. & Hodgkin, J. in The Nematode Caenorhabditis elegans (Cold Spring Harbor Laboratory, New York, 1988).

    Google Scholar 

  46. Schwartz, D. C. & Cantor, C. R. Cell 37, 67–75 (1984).

    Article  CAS  PubMed  Google Scholar 

  47. Sigurdson, D. C., Spanier, G. J. & Herman, R. K. Genetics 108, 331–345 (1984).

    CAS  PubMed  PubMed Central  Google Scholar 

  48. Kramer, J. M., French, R. P., Park, E. & Johnson, J. J. Molec. cell Biol. 10, 2081–2089 (1990).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. Maniatis, T., Fritsch, E. F. & Sambrook, J. Molecular Cloning: A Laboratory Manual Cold Spring Harbor Laboratory, New York, 1982).

    Google Scholar 

  50. Barstead, R. J. & Waterston, R. H. J. biol. Chem. 264, 10177–10185 (1989).

    CAS  PubMed  Google Scholar 

  51. Henikoff, S. Gene 8, 351–359 (1984).

    Article  Google Scholar 

  52. Cotton, R. G. H., Rodrigues, N. R. & Duncan Campbell, R. Proc. natn. Acad. Sci. U.S.A. 85, 4397–4401 (1988).

    Article  ADS  CAS  Google Scholar 

  53. Schejter, E. D., Segal, D., Glazer, L. & Shilo, B. Cell 46, 1091–1101 (1986).

    Article  CAS  PubMed  Google Scholar 

  54. Anderson, S. K., Gibbs, C. P., Tanaka, A., Kung, H. & Fujita, D. J. Molec. cell Biol. 5, 1122–1129 (1985).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Shtivelman, E., Lifshitz, B., Gale, R. P., Roe, B. A. & Canaani, E. Cell 47, 277–284 (1986).

    Article  CAS  PubMed  Google Scholar 

  56. Ullrich, A. et al. Nature 313, 576–761 (1985).

    Article  Google Scholar 

  57. Yarden, Y. et al. Nature 323, 226–232 (1986).

    Article  ADS  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Howard Hughes Medical Institute, Division of Biology, California Institute of Technology, Pasadena, California, 91125, USA

    Raffi V. Aroian, Jane E. Mendel & Paul W. Sternberg

  2. Department of Biology, Faculty of Science, Kyushu University, Higashi-ku, Fukuoka, 812, Japan

    Makoto Koga & Yasumi Ohshima

Authors
  1. Raffi V. Aroian
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  2. Makoto Koga
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  3. Jane E. Mendel
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  4. Yasumi Ohshima
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  5. Paul W. Sternberg
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Aroian, R., Koga, M., Mendel, J. et al. The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily. Nature 348, 693–699 (1990). https://doi.org/10.1038/348693a0

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