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Clathrin light chains contain brain-specific insertion sequences and a region of homology with intermediate filaments

Nature volume 326, pages 154–159 (1987)Cite this article

The primary structures of four bovine clathrin light chains have been determined. Light chains LCa and LCb are homologous proteins encoded by different genes. In the brain the messenger RNA from these genes undergoes differential splicing to yield proteins having centrally inserted brain-specific sequences. A potentially α-helical region of the clathrin light chains shows homology with intermediate filament proteins.

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Author notes

  1. Nicholas Holmes & Kurt Drickamer

    Present address: Department of Biochemistry, Columbia University, New York, 10032, New York, USA

  2. Peter Parham

    Present address: Division of Immunology, Department of Pathology, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge, CB2 2QQ, UK

  3. Kurt Drickamer: Department of Biochemistry, University of Chicago, Chicago, Illinois 60637, USA

Authors and Affiliations

  1. Department of Cell Biology, Fairchild Science Building, Stanford University, Stanford, California, 94305, USA

    Antony P. Jackson, Heng-Fong Seow, Nicholas Holmes, Kurt Drickamer & Peter Parham

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  1. Antony P. Jackson
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  3. Nicholas Holmes
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  5. Peter Parham
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Jackson, A., Seow, HF., Holmes, N. et al. Clathrin light chains contain brain-specific insertion sequences and a region of homology with intermediate filaments. Nature 326, 154–159 (1987). https://doi.org/10.1038/326154a0

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