Nature 312, 521 - 524 (06 December 1984); doi:10.1038/312521a0

Sequence and expression of transcripts of the human T-cell receptor - chain genes

Yasunobu Yoshikai, Demetri Anatoniou^*, Stephen P. Clark, Yusuke Yanagi, Robert Sangster, Peter Van den Elsen^*, Cox Terhorst^* & Tak. W. Mak

The Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, 500 Sherbourne Street, Toronto, Ontario, Canada M4X 1K9
^*Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA

T lymphocytes can produce mRNAs from the first or second constant region of the T-cell antigen receptor -chain. A 1.3-kilobase (kb) transcript encoding the mature protein contains V, J and one of the two C region sequences, but does not always contain D sequences. A 1.0-kb mRNA, found mainly in immature T cells, does not contain V sequences and can result from transcription that initiates upstream from an unrearranged J element.

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