Abstract
DENGUE VIRUSES, which have four serotypes, belong to the genus flavivirus of Togaviridae and are transmitted by mosquitoes such as Aedes aegypti or Aedes albopictus. Human infection with dengue viruses is manifested by disease varying in severity from mild undiflferentiated fever to grave haemorrhagic fever, which is widespread in Southeast Asia1–3. Persistently infected cultures can be established when cultured mosquito cells are infected with Togaviridae, either alphaviruses or flavi viruses4–7. Analysis of mosquito cells persistently infected with alphaviruses has shown characteristics such as the generation of small-plaque and temperature-sensitive (ts) viruses7–9, and resistance to superinfections with the homologous but not the heterologous viruses6,10. In contrast, little is known about mosquito cells persistently infected with flavi viruses4,11,12. Here, in experiments with A. albopictus (Singh) cells persistently infected with dengue viruses, I show that such cultures produce ts viruses and become resistant to all the types of dengue viruses.
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IGARASHI, A. Characteristics of Aedes albopictus cells persistently infected with dengue viruses. Nature 280, 690–691 (1979). https://doi.org/10.1038/280690a0
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DOI: https://doi.org/10.1038/280690a0
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