Abstract
ALTHOUGH there has been speculation about the healing powers of saliva, recent interest in the salivary glands has been concerned with the physiology of nerve growth factor and epidermal growth factor1–4. However, saliva also contains other biologically active substances such as kallikrein5,6, amylase7, lysozyme8, immunoglobulins9 and renin10. Lysozyme is believed to enhance healing by suppressing infection11. The wound healing process can be divided into epithelialisation, contraction, collagen synthesis and scar remodelling12: the evidence presented here suggests that contraction is affected by the salivary glands.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Pasquini, F. et al. Expl Cell Res. 86, 233–236 (1974).
Ekfors, T. O. & Hopsu-Havu, V. K. Histochem. J. 3, 415–420 (1971).
Gresik, E. & Barka, T. J. Histochem. Cytochem. 25, 1027–1035 (1977).
Van Noorden, S., Hietz, P., Kasper, M. & Pearse, A. G. E. Histochemistry 52, 329–340 (1977).
Maranda, B., Rodrigues, J. A. A., Schachter, M., Shnitka, T. K. & Weinberg, J. J. Physiol., Lond. 276, 321–328 (1978).
Brandtzaeg, P., Gautvik, K. M., Nustad, K. & Pierce, J. V. Br. J. Pharmac. 56, 155–167 (1976).
Ellison, S. A. in Handbook of Physiology Sect. 6, Vol. 2 (ed. Code, C. F.) 538–539 (Williams and Wilkins, Baltimore, 1967).
Fleming, A. Proc. R. Soc. B93, 306–317 (1922).
Kraus, F. W. & Mestecky, J. Archs oral Biol. 16, 781–789 (1971).
Cozzari, C., Angeletti, P. U., Lazar, J., Orth, H. & Gross, F. Biochem. Pharmac. 22, 1321–1327 (1973).
Burgen, A. S. V. & Emmelin, N. G. Monogr. physiol. Soc. No. 8, 258 (Arnold, London, 1961).
Peacock, E. E. Jr & Van Winkle, W. Jr Wound Repair 2nd edn, 22–53 (Saunders, Philadelphia, 1976).
Billingham, R. E. & Russell, P. S. Ann. Surg. 144, 961–981 (1956).
Grillo, H. C., Watts, G. T. & Gross, J. Ann. Surg. 148, 145–152 (1958).
Lindquist, G. Acta chir. scand. 94, Suppl 107, 1–63 (1946).
Young, J. S., Fisher, J. A. & Young, M. J. path. Bact. 52, 225–246 (1941).
Guber, S. & Rudolph, R. Surg. Gynec. Obstet. 146, 641–649 (1978).
Gabbiani, G., Ryan, G. B. & Majno, G. Experientia 27, 549–550 (1971).
Morton, D. Jr, Madden, J. W. & Peacock, E. E. Jr Surg. Forum 23, 511–512 (1972).
Kroeger, D. C. & Weatherred, J. G. in Advances in Oral Biology Vol. 2 (ed. Staple, P. H.) 32–65 (Academic, New York, 1966).
Rudolph, R., Guber, S., Suzuki, M. & Woodward, M. Surg. Gynec. Obstet. 145, 389–394 (1977).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
HUTSON, J., NIALL, M., EVANS, D. et al. Effect of salivary glands on wound contraction in mice. Nature 279, 793–795 (1979). https://doi.org/10.1038/279793a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/279793a0
This article is cited by
-
Cortical regulation of helping behaviour towards others in pain
Nature (2024)
-
Deterioration in saliva quality in patients with Sjögren’s syndrome: impact of decrease in salivary epidermal growth factor on the severity of intraoral manifestations
Inflammation and Regeneration (2018)
-
Submandibular salivary glands: influence on growth rate and life span in mice
Journal of Physiology and Biochemistry (2011)
-
Chaperonin containing T-complex polypeptide (CCT) subunit expression in oral mucosal wounds and fibroblasts
Cell Stress and Chaperones (2011)
-
Lessons Learned from Psoriatic Plaques Concerning Mechanisms of Tissue Repair, Remodeling, and Inflammation
Journal of Investigative Dermatology Symposium Proceedings (2006)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.
