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Article
Nature 264, 722-727 (23 December 1976) | doi:10.1038/264722a0; Accepted 26 October 1976
Somatic mutation as the basis for malignant transformation of BHK cells by chemical carcinogens
Noël Bouck & Giampiero di Mayorca
- Department of Microbiology, University of Illinois at the Medical Center, Chicago, Illinois 60612
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Abstract
The chemical induction of malignant transformation in BHK cells seems to result from a somatic mutation. Stable transformants, whose frequency is significantly increased by mutagenic carcinogens, can revert to normal and often display temperature-restricted phenotypes indicative of an altered gene product.
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