Abstract
TREATMENT of normal cells1–6 or some established cell lines7 in culture with chemical carcinogens can result in cell transformation and malignancy. Cells which have an oriented pattern of cell growth, a limited life span in vitro and are not tumorogenic in vivo, are then converted into cells with a hereditary random pattern of cell growth, an ability to grow continuously in culture and to form tumours in vivo. Studies with a variety of polycyclic hydrocarbons and other chemicals have shown a correlation between the frequency of colonies with a hereditary random pattern of cell growth (transformed colonies) and the degree of carcinogenicity in animals2,6,7.
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HUBERMAN, E., MAGER, R. & SACHS, L. Mutagenesis and transformation of normal cells by chemical carcinogens. Nature 264, 360–361 (1976). https://doi.org/10.1038/264360a0
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DOI: https://doi.org/10.1038/264360a0
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