Abstract
THE use of immunoadjuvants in tumour therapy is based largely on the concept that an increased level of specific immunity against tumour-associated antigens may be achieved by nonspecific stimulation of the immune system (for review see ref. 1). Among these adjuvants, Corynebacterium parvum has received much attention since it represents one of the most powerful stimulants of the reticuloendothelial system in mice2, and is effective in inhibiting tumour growth in several animal tumour systems (for example, see refs 3–6). The mechanisms by which C. parvum interferes with tumour growth have not been established and the tumour protective effect of C. parvum has not been entirely consistent in all systems studied. An immunosuppressive effect of C. parvum has been demonstrated too. In mice, the in vitro lymphoproliferative responses to mitogens and to alloantigens were depressed after injection of C. parvum. It remains to be determined, however, whether a defect measured by these general tests of T lymphocytes may also represent an indication of depressed cell-mediated immunity against tumour cells.
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KIRCHNER, H., GLASER, M. & HERBERMAN, R. Suppression of cell-mediated tumour immunity by Corynebacterium parvum. Nature 257, 396–398 (1975). https://doi.org/10.1038/257396a0
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DOI: https://doi.org/10.1038/257396a0
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