Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Article
  • Published:

Size and location of the transforming region in human adenovirus type 5 DNA

Abstract

Fragments of human adenovirus type 5 DNA as small as one million daltons can transform cells in vitro. The DNA segment which induces transformation is located between 1 and 6% from the left end of the Ad 5 DNA molecule.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. van der Eb, A. J., van Kesteren, L. W., and van Bruggen, E. F. J., Biochem. biophys. Acta, 182, 530–541 (1969).

    CAS  PubMed  Google Scholar 

  2. Green, M., Pina, M., Kimes, R., Wensink, P. C., MacHattie, L. A., and Thomas, C. A., jun., Proc. natn. Acad. Sci., U.S.A., 57, 1302–1309 (1967).

    Article  ADS  CAS  Google Scholar 

  3. Schlesinger, R. W., in Advances in Virus Research (edit. by Smith, K. W., and Lauffer, M. A.) 14, 1–61 (Academic Press, New York and London, 1969).

    Google Scholar 

  4. Trentin, J. J., van Hoosier, G. L., and Samper, L., Proc. Soc. exp. Biol. Med., 127, 683–689 (1968).

    Article  CAS  Google Scholar 

  5. Freeman, A. E., Black, P. H., Vanderpool, E. A., Henry, P. H., Austin, J. B., and Heubner, R. J., Proc. natn. Acad. Sci., U.S.A., 58, 1205–1212 (1967).

    Article  ADS  CAS  Google Scholar 

  6. Williams, J. F., and Ustacelebi, S., in Ciba Foundation Symposium on Strategy of the Viral Genome (edit. by Wolstenholme, G. E. W., and O'Connor, M.) 275–290 (Churchill and Livingstone, London, 1971).

    Google Scholar 

  7. Gallimore, P. H., J. gen. Virol., 16, 99–102 (1972).

    Article  CAS  Google Scholar 

  8. Williams, J. F., Nature, 243, 162–163 (1973).

    Article  ADS  CAS  Google Scholar 

  9. Graham, F. L., and van der Eb, A. J., Virology, 52, 456–467 (1973).

    Article  CAS  Google Scholar 

  10. Graham, F. L., and van der Eb, A. J., Virology, 54, 536–539 (1973).

    Article  CAS  Google Scholar 

  11. Burnett, J. P., and Harrington, J. A., Proc. natn. Acad. Sci., U.S.A., 60, 1023–1029 (1968).

    Article  ADS  CAS  Google Scholar 

  12. Graham, F. L., Veldhuisen, G., and Wilkie, N. M., Nature, 245, 265–266 (1973).

    CAS  Google Scholar 

  13. Studier, F. W., J. molec. Biol., 11, 373–390 (1965).

    Article  CAS  Google Scholar 

  14. Kimes, R., and Green, M., J. molec. Biol., 50, 203–206 (1970).

    Article  CAS  Google Scholar 

  15. Doerfler, W., and Kleinschmidt, A. K., J. molec. Biol., 50, 579–593 (1970).

    Article  CAS  Google Scholar 

  16. Nandi, U. S., Wang, J. C., and Davidson, N., Biochemistry, 4, 1687–1696 (1965).

    Article  CAS  Google Scholar 

  17. Richardson, C. C., Lehman, I. R., and Kornberg, A., J. biol. Chem., 239, 251–258 (1964).

    CAS  PubMed  Google Scholar 

  18. Garon, F. C., Berry, K. W., and Rose, J. A., Proc. natn. Acad. Sci., U.S.A., 69, 2391–2395 (1972).

    Article  ADS  CAS  Google Scholar 

  19. Wolfson, J., and Dressler, D., Proc. natn. Acad. Sci. U.S.A., 69, 3054–3057 (1972).

    Article  ADS  CAS  Google Scholar 

  20. Signer, E. R., Ann. Rev. Microbiol., 22, 451–488 (1968).

    Article  CAS  Google Scholar 

  21. Yamamoto, H., Jap. J. Microbiol., 14, 487–493 (1970).

    CAS  PubMed  Google Scholar 

  22. Green, M., Ann. Rev. Biochem., 39, 701–756 (1970).

    Article  CAS  Google Scholar 

  23. Heijneker, H. L., Ellens, D. J., Tjeerde, R. H., Glickman, B. W., van Dorp, B., and Pouwels, P. H., Molec. gen. Genet., 124, 83–96 (1973).

    Article  CAS  Google Scholar 

  24. Jovin, T. M., Englund, P. T., and Bertsch, L. L., J. biol. Chem., 244, 2996–3008 (1969).

    CAS  PubMed  Google Scholar 

  25. Vogt, V. M., Eur. J. Biochem., 33, 192–200 (1973).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Graham, F., van der Eb, A. & Heijneker, H. Size and location of the transforming region in human adenovirus type 5 DNA. Nature 251, 687–691 (1974). https://doi.org/10.1038/251687a0

Download citation

  • Received:

  • Revised:

  • Issue Date:

  • DOI: https://doi.org/10.1038/251687a0

This article is cited by

Comments

By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing