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Nature 246, 425 - 427 (14 December 1973); doi:10.1038/246425a0

Morphine-induced Suppression of Voluntary Alcohol Drinking in Rats


*Research Laboratories of the State Alcohol Monopoly (ALKO), 00101 Helsinki 10
Department of Psychology, Sangamon State University, Springfield, Illinois
Department of Psychology, University of Oregon, Eugene, Oregon

A DEBATE has arisen over whether there is a relationship between alcohol and morphine addictions. With the classical phenomena associated with addiction there is little or no evidence for a connection between the two drugs1–4. The short-term effects are different, the withdrawal symptoms are different, morphine antagonists do not precipitate withdrawal in alcohol-dependent animals, and usually no cross-dependencies or cross-tolerances have been found, although there are reports of increased tolerance for morphine in mice that have been habituated to alcohol5 and in some human alcoholics6.



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