Abstract
WE have previously reported1 the results of our study demonstrating a circadian variation in the susceptibility of groups of rats to a lethal dose of methadone. The statistical significance of this finding has been criticized by Argyle2, who proposed the binomial test as a more appropriate indicator of the significance of the data. Additional experiments not only support the conclusions of the earlier work, but have also provided an opportunity for a more rigorous statistical test of our hypotheses.
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References
Lenox, R. H., and Frazier, T. W., Nature, 239, 397 (1972).
Argyle, E., Nature, 242, 332 (1973).
Scheving, L. E., Vedral, D. F., and Pauly, J. E., Nature, 219, 621 (1968).
Armitage, P., Statistical Methods in Medical Research (Blackwell Scientific Publications, Oxford and Edinburgh, 1971).
Reinberg, A., and Halberg, F., Ann. Rev. Pharmacol., 11, 455 (1971).
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LENOX, R., FRAZIER, T. Methadone Induced Mortality as a Function of the Circadian Cycle. Nature 244, 101–102 (1973). https://doi.org/10.1038/244101a0
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DOI: https://doi.org/10.1038/244101a0
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