Nature Publishing Group, publisher of Nature, and other science journals and reference works
Nature
my account e-alerts subscribe register
   
Sunday 25 June 2017
Journal Home
Current Issue
AOP
Archive
Download PDF
References
Export citation
Export references
Send to a friend
More articles like this

Letters to Nature
Nature 232, 471 - 473 (13 August 1971); doi:10.1038/232471a0

Quantitative Evidence for Protein Denaturation as the Cause of Thermal Death

BARNETT ROSENBERG, GABOR KEMENY, ROBERT C. SWITZER & THOMAS C. HAMILTON

Department of Biophysics, Michigan State University, East Lansing, Michigan 48823

THE specific cause of the death rates of unicellular organisms and poikilothermic animals at high temperatures is not known for certain1. We wish to report a good numerical correlation between certain thermodynamic parameters in protein denaturation and death rates, where these have been reported, for these organisms. A similar correlation may exist between the thermal denaturation of other biopolymers, such as DNA and RNA, and thermal death, but in the absence of adequate data we cannot consider this possibility further.

------------------

References

1. Strehler, B. L., Time, Cells and Aging (Academic Press, New York, 1962).
2. Glasstone, S., Laidler, K. J., and Eyring, H., The Theory of Rate Processes (McGraw-Hill, New York, 1941).
3. Williams, T. P., and Milby, S. E., Vision Res., 8, 359 (1968). | Article | PubMed | ISI | ChemPort |
4. Rosenberg, B., and Williams, T. P., Vision Res. (in the press).
5. Eley, D. D., J. Polymer Sci., Pt C, 17, 73 (1967).
6. Rosenberg, B., Bhowmik, B. B., Harder, H. C., and Postow, E., J. Chem. Phys., 49, 4108 (1968). | Article | ChemPort |
7. Lumry, R., and Rajender, S., Biopolymers, 9, 1125 (1970). | Article | PubMed | ISI | ChemPort |
8. McCreary, J. R., and Thorn, R. J., J. Chem. Phys., 50, 3725 (1969). | Article | ChemPort |
9. Leffler, J., and Grunwald, E., Rates and Equilibria of Organic Reactions (Wiley, New York, 1963).
10. Exner, O., Nature, 201, 488 (1964). | ChemPort |
11. Joly, M., A Physico-chemical Approach to Denaturation of Proteins (Academic Press, New York, 1965).
12. Sukhorukov, B. I., and Likhtenshtein, G. I., Biofizika, 10, 935 (1965). | PubMed | ChemPort |
13. van Uden, N., Abranches, P., and Cabeca-Silva, C., Archiv. Mikrobiol., 61, 381 (1968). | ChemPort |
14. Barnes, R., Vogel, H., and Gordon, I., Proc. US Nat. Acad. Sci., 62, 263 (1969). | ChemPort |
15. Luedecke, L. O., thesis, Michigan State Univ. (1962).
16. Walker, G. C., thesis, Michigan State Univ. (1964).
17. Beamer, P. R., and Tanner, F. W., Zentralblatt Bakt., 100, 81 (1939).
18. Strehler, B. L., J. Gerontol., 16, 2 (1961). | ChemPort |



© 1971 Nature Publishing Group
Privacy Policy